Currently, tokamaks operated in pulsed scenarios where the vessel is constantly pumped out, and fresh gas is pumped in during each shot. Future advanced tokamaks will try to operate in steady state. This means that there will be some fraction of the plasma ions will be helium ash, which dilutes the fuel. The helium is gradually removed as some plasma escapes the edge of the magnetic confinement. There are a few methods devised to accelerate the removal.
RF waves can induce transport of the helium ions. He1+ has a different resonant frequency than D+ and T+, so it can be driven out. But the difficulty is that most of the helium is in the He2+ state, which has the same resonant frequency as D+ and T+.
We can use magnetic coils to control something called edge localized modes which are instabilities in the plasma which pump out particles at the plasma edge. But to be honest, they pump out both helium and fuel ions.
There's something called I-mode in which energy is confined better than the particles. It's kind of weird to think about since particles carry the energy of the plasma, but there is some collective behavior which lower energy particles escape. The upside is that it can allow relatively fast removal of impurities and ash while maintaining a high temperature required for fusion. But some fuel will also leak out.
The helium and fuel that escapes the plasma is diverted toward a divertor, which can be used to separate helium and fuel to some degree. There are cyropumps in the divertor which can be optimized to pump helium. See
https://arxiv.org/abs/1311.4689 for one concept.
This paper [
http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/42426/1/169_55-60.pdf] talks about using materials such as nickel in the divertor to trap helium ions selectively.
Unfortunately, existing methods are far from perfect, so there will be some steady state helium in the fusion reactor.