The derivative of 5*sqrt[x] can be calculated using the power rule, resulting in 2.5x^(-1/2). While some participants suggested using the product and chain rules, it was noted that this approach adds unnecessary complexity. The general power rule is simpler and more efficient for this type of function. The discussion concluded that applying the power rule directly is the best method for finding the derivative in this case. Overall, the consensus is that the initial derivative calculation is correct and straightforward.