Voltage is defined as the potential difference between two points, while current refers to the rate of charge flow over time. Resistance is proportional to voltage and inversely proportional to current, affecting how much current can flow in a circuit. Internal resistance, related to the efficiency of power sources, adds to the total resistance in a circuit and can lead to energy dissipation as heat. It is impossible to create a device with zero internal resistance, although in some scenarios, it can be negligible compared to the load resistance. Understanding these concepts is crucial for analyzing electrical circuits effectively.