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Molecular machinery - Mechanism of action?

  1. Dec 15, 2011 #1
    I'm watching a fascinating video about DNA replication:

    Can someone explain briefly what the mechanism of action (and locomotion) is for all these little machines? Is it simply electric potential (due to ionization?) ?

    Last edited by a moderator: Sep 25, 2014
  2. jcsd
  3. Dec 15, 2011 #2


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    The quick explanation pretty much given in other vids at same site such as http://www.youtube.com/watch?feature=endscreen&NR=1&v=teV62zrm2P0

    Otherwise any book of molecular biology.

    In brief to your question what drives it, in the immediate you could say it is free energy of posphoanhydrides in one or other kind of phosphate transfer to form phophodiesters in particular. If you ask how the phophoanhydrides are formed they do go back in the end to a sort of transmembrane potential difference but that is not the only mechanism. Others involve yet other purely chemical phosphate group transfers. Phosphate transfers must be about half of all the reactions of biochemistry, and if not they seem like it.

    Read a book, your question cannot really be answered in a post.
  4. Dec 17, 2011 #3
    Basically the energy required is derived from the hydrolysis of the to be formed nucleotide itself. You can check the reaction mechanism here.
    wiki.cstl.semo.edu/agathman/DNA polymerase.ashx
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