Non-equilibrium thermodynamics

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SUMMARY

Non-equilibrium thermodynamics governs biological systems, which act as dissipative structures while adhering to the universal laws of thermodynamics. The discussion centers on the theoretical possibility of using a Carnot engine to limit entropy generation in biological systems, particularly cancer cells, which exhibit increased entropy and exergonic behavior. Participants clarify that while Carnot engines are not practically realizable, the concept raises questions about the relationship between entropy control and tumor growth. Ultimately, the consensus indicates that controlling entropy in biological systems is complex and not straightforwardly achievable through mechanical means.

PREREQUISITES
  • Understanding of non-equilibrium thermodynamics
  • Familiarity with the Carnot engine and its theoretical principles
  • Basic knowledge of cancer biology and cellular metabolism
  • Concept of entropy in thermodynamics
NEXT STEPS
  • Research the principles of non-equilibrium thermodynamics in biological systems
  • Explore the theoretical applications of Carnot engines in biological contexts
  • Investigate the relationship between entropy and cancer cell metabolism
  • Study the mechanisms of tumor growth and the role of DNA damage in cancer
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Biologists, physicists, cancer researchers, and anyone interested in the intersection of thermodynamics and biological systems.

vjrajsingh
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Biological systems act as dissipative structures and obey the universal laws of thermodynamics in spite of being open structures as they follow non-equilibrium thermodynamics. In accordance with the second law, entropy generation occurs. Is it possible to limit the entropy generation in a biological system using an engine? A Carnot engine, for example, is supposed to make the entropy level constant. How would this engine operate if it could at all?
 
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"Is it possible to limit the entropy generation in a biological system using an engine?" Can you explain which "biological system" you are replacing? Can you reference a Carnot cycle engine that actually exists?
 
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shjacks45 said:
"Is it possible to limit the entropy generation in a biological system using an engine?" Can you explain which "biological system" you are replacing? Can you reference a Carnot cycle engine that actually exists?
Yes. I'm sorry if I may sound naive but it's only because my background is in biology. I only just started exploring physics. Cancer cells generally show a massive rise in entropy and are exergonic.
And I know Carnot engines don't exist practically. I'm only asking if it's possible in theory to use a bioengine that works along these same principles to turn entropy generation of this system constant
 
shjacks45 said:
"Is it possible to limit the entropy generation in a biological system using an engine?" Can you explain which "biological system" you are replacing? Can you reference a Carnot cycle engine that actually exists?
Do you mean to say that we'll have to replace the whole system with an engine? Does that mean replacing a complete tumor?
 
If we take out the tumor why are we replacing it?
 
vjrajsingh said:
Yes. I'm sorry if I may sound naive but it's only because my background is in biology. I only just started exploring physics. Cancer cells generally show a massive rise in entropy and are exergonic.
And I know Carnot engines don't exist practically. I'm only asking if it's possible in theory to use a bioengine that works along these same principles to turn entropy generation of this system constant
Still don't understand why one needs to control the entropy in a biological system. A tumor is a normal cell whose feedback mechanisms controlling growth are damaged. There are no new or different cell mechanisms. Tumors are often fast growing, and will probably be warmer due to metabolic activity. I have never seen cancer research refer to a tumor's "entropy". Antimetabolic drugs/radiation affects other fast growing cells like hair. Skin, and intestinal lining; as well as tumor cells. At first I thought you were looking to replace mitochondria to make cells more efficient. But you can't just couple a shaft like a physical engine, you would need to address the thousands of (but finite) chemical and DNA connections that cells have with mitochondria. Note the same less efficient energy pathways like glucose-6-phosphate shunt is used by red blood cells.
vjrajsingh said:
Yes. I'm sorry if I may sound naive but it's only because my background is in biology. I only just started exploring physics. Cancer cells generally show a massive rise in entropy and are exergonic.
And I know Carnot engines don't exist practically. I'm only asking if it's possible in theory to use a bioengine that works along these same principles to turn entropy generation of this system constant
My background was biochemistry. "Cancer cells generally show a massive rise in entropy and are exergonic." So cancer cells waste energy and give off heat. Both the heart and the brain use energy inefficiently and give off more heat than other cells at rest. And how/why "measure" entropy? Entropy can't be directly measured, but is derived from other thermodynamic measurements. Sounds like you think bringing a cancer cell's entropy down will stabilize a tumor? No. Cancer is due to damaged DNA.
 

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