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sumzup
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- My understanding is that for EAS, Friedel-Crafts Acylations/Alkylations will only work for halobenzenes or better (in terms of electron donating groups). Does this mean that F-C won't work for a halobenzene that also has a nitro group on it, due to the extreme withdrawing effects of the nitro group?
- I know that compounds like 1,2-ethanediol can be used to protect aldehydes and ketones; since sulfur is in the same group as oxygen and reacts similarly, can something like HOCH2CH2SH or HSCH2CH2SH be used to protect aldehydes/ketones?
- On a related note, is the protecting of aldehydes/ketones affected by the Khydrate (just like with addition of KCN or NaCN to a carbonyl group)?
- When performing fischer esterification for a lab recently, most people's reactions turned purple (although mine didn't, for some reason); my TA mentioned that it had something to do with the sulfuric acid. Why/how would this be the case?
Oh, and just to be clear, these aren't homework questions. Just stuff I want to know the answers to.