The discussion centers on the issue of Mathematica's FullSimplify function not simplifying the expression a + Sqrt[b + c] - Sqrt[a^2 + b + c + 2 a Sqrt[b + c]] to zero, despite assumptions that a, b, and c are positive. The reason provided is that the simplification process retains all possible outcomes, including cases where Sqrt can yield both positive and negative results. Users suggest explicitly guiding Mathematica to use the positive square root or squaring both sides to eliminate ambiguity. The conversation highlights the limitations of computer algebra systems in handling assumptions and the need for precise instructions to achieve desired simplifications. Overall, the thread emphasizes the importance of understanding how Mathematica interprets mathematical expressions under given assumptions.