Progress on an Alzheimer's vaccine?

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Discussion Overview

The discussion revolves around the potential development of vaccines for Alzheimer's disease, examining both scientific research and public perceptions. Participants explore the implications of recent findings, the effectiveness of proposed vaccines, and the underlying causes of Alzheimer's.

Discussion Character

  • Exploratory
  • Debate/contested
  • Technical explanation

Main Points Raised

  • Some participants express interest in recent articles discussing progress on Alzheimer's vaccines, highlighting the potential benefits of such advancements.
  • Others suggest that the excitement surrounding these vaccines may be overstated, likening it to a financial rush rather than a genuine scientific breakthrough.
  • One participant argues that current vaccines do not address the root causes of Alzheimer's, focusing instead on symptoms related to plaque formation.
  • A later reply introduces the discovery of meningeal lymphatic vessels in rats, proposing that this could be a significant factor in understanding Alzheimer's, though confirmation in humans remains uncertain and challenging.
  • Another participant notes that while there have been numerous studies since the 2000s targeting proteins like Tau and beta-amyloid, the vaccines have been associated with serious side effects, complicating their development.

Areas of Agreement / Disagreement

Participants do not reach a consensus; there are multiple competing views regarding the effectiveness and implications of Alzheimer's vaccines, as well as the understanding of the disease itself.

Contextual Notes

Participants highlight limitations in current knowledge about the brain and the complexities involved in confirming new discoveries related to Alzheimer's. There are also concerns about the safety and efficacy of existing vaccine trials.

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These vaccines don't address the cause of Alzheimers, they just treat symptoms that manifest during and after plaque formation begins. The paper is obviously prepping products for the market.

But looky here, we don't know as much about the brain as we are led to believe, very recently meningeal lymphatic vessels were discovered (in rats) and its roles are thought to be fundamental in the nervous system, which makes a possible major contributor to Alzheimers and other diseases. It's still in the preliminary stages, but I wager that there are many hands out their with hands just itching to dissect human brains to confirm the discoveries. I think the confirmation will be more tedious though, from what I gather, the staining/imaging techniques will have to be specifically tailored to confirm the discovery in humans. I cannot believe this has been missed for so long though, it's mind-blowing really.
 
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There have been lots of studies starting in the 2000's this links to a number of grants awarded for trails of vaccines against Tau and beta-amyloid, these proteins and associated inflammation appear to be the target of drug research as well with a monoclonal antibody (Solanezumab) already in trails. So far the vaccines have been associated with dangerous side effects and it appears to be difficult to get around these.

arch.asp?cof=FORID%3A11&ie=UTF-8&q=vaccine&sa.x=0&sa.y=0&cx=004371536981038018237%3Anouzcixprg4

The website of http://www.alz.org/index.asp has lots of information.
 
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