Hi, i have a question bout the chloride shift that occurs in the red blood cell. After the carbon dioxide has dissociated into the Red Blood Cell's plasma and became H+ and HCO3- i would like to know why must the HCO3- must go out and combine with the Sodium ions and since the H+ ions have combined with Hemoglobin, Hb. Why is Cl- still needed and shifted into the Red Blood Cell? Doesn't H.Hb is already neutralized? Sorry if you think this is a very easy question, but my book just told me there is a chloride shift, there is no explanation given on the mechanism. Thanks.