The discussion centers around the concept of the "organic chemistry" class in math, which many participants identify as the junior-level Intro to Real Analysis. This course is perceived as a significant hurdle for math majors, often described humorously as the class that converts math students into engineers due to its abstract nature and limited practical application. Participants share their experiences with various math classes, noting that while some find calculus straightforward, others struggle with it, particularly in advanced topics like differential equations and integrals. Linear algebra is generally viewed as easier, but experiences vary significantly based on teaching styles and course structure. Abstract algebra and topology are frequently mentioned as particularly challenging subjects. Overall, the conversation highlights the subjective nature of difficulty in math courses and the influence of teaching methods on student experiences.