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Silent mutation and third position

  1. Nov 21, 2018 #1
    I got this question in an exam. Why do silent mutations always affect the third position of a codon? I have no clue about it.
  2. jcsd
  3. Nov 21, 2018 #2
    A quick google gave me some information on this, have you had a look?
  4. Nov 21, 2018 #3


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    Science Advisor

    They don't always affect the third position, but they are definitely more common at the third position. Read up on how tRNAs recognize codons during translation.
  5. Nov 21, 2018 #4
    The search keywords "wobble base" might help.
  6. Dec 6, 2018 #5
    I'm sorry I didn't do my research properly before posting this question. @pinball1970

    Thanks to both of you. @JonMoulton & @Ygggdrasil

    I'll soon reply with an answer.
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