To solve the polynomial expression (4(x^3)+38(x^2)+44x-20)/(20+12x+x^2), one can simplify it by factoring the numerator and performing polynomial long division. Finding when the function equals zero involves identifying values of x that make the numerator zero, typically through factoring or using the rational roots theorem for potential integer solutions. For higher-order polynomials, roots can be determined using methods such as the one developed by Scipio del Ferro, which involves changing variables and solving cubic equations. However, equations of the fifth degree and higher cannot be solved using simple formulas and require numerical methods like Newton's method for approximation. Understanding these techniques is essential for tackling complex polynomial equations effectively.