Toxicology Resources: Wikipedia, Principles of Biochemical Toxicology & More

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SUMMARY

This discussion provides a comprehensive list of resources for studying toxicology, including Wikipedia templates on toxins, toxicology, and poisoning. Key references include "Principles of Biochemical Toxicology" and the Comparative Toxicogenomics Database (CTD). The conversation highlights the significance of predicting toxicity based on chemical structure, with links to relevant research papers and databases such as PharmGKB and the Carcinogenic Potency Project. Additionally, it addresses specific toxins like Ochratoxin and Tetrodotoxin, emphasizing their relevance in neurophysiology research.

PREREQUISITES
  • Familiarity with toxicology concepts and terminology
  • Understanding of chemical structure and its relation to toxicity
  • Knowledge of pharmacogenomics and its applications
  • Basic research skills to navigate scientific databases and literature
NEXT STEPS
  • Explore the Comparative Toxicogenomics Database (CTD) for chemical-gene interactions
  • Investigate QSAR models for predicting chemical toxicity
  • Research the latest findings in computational toxicology and protein folding
  • Review case studies on specific toxins like Tetrodotoxin and their implications in neurophysiology
USEFUL FOR

This discussion is beneficial for toxicologists, pharmacologists, researchers in biochemical fields, and anyone interested in the effects of chemicals on health and the environment.

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http://en.wikipedia.org/wiki/Template:Toxins => Wikipedia template on toxins

http://en.wikipedia.org/wiki/Template:Toxicology => Wikipedia toxicology template

http://en.wikipedia.org/wiki/Template:Poisoning_and_toxicity

http://books.google.com/books?id=jW...&dq=toxicology&ei=2aiFTf-BOYKglATgv_yjAQ&cd=1 => Principles of Biochemical Toxicology

http://ctd.mdibl.org/query.go?type=ixn =>Chemical–Gene Interaction Query - CTD

http://www.pharmgkb.org/ => The Pharmacogenomics Knowledge Base [PharmGKB]

http://potency.berkeley.edu/ => The Carcinogenic Potency Project (CPDB)

http://www.reactome.org/ReactomeGWT/entrypoint.html#FrontPage.3625

http://ctd.mdibl.org/ => The Comparative Toxicogenomics Database - CTD

http://en.wikipedia.org/wiki/Toxicogenomics

Nice Physics Forums replies to toxicologically significant properties:

mg/kg - how relevant?: https://www.physicsforums.com/showthread.php?t=462694

protein folding/computational toxicology: https://www.physicsforums.com/showthread.php?t=466253

Predicting toxicity based on chemical structure (this is a VERY hot field for research right now):

http://potency.berkeley.edu/pdfs/structure_tox_on_web.pdf

http://books.google.com/books?id=-C...LilASt08XNBw&cd=4#v=onepage&q=organic&f=false => A comprehensive guide to the hazardous properties of chemical substances

http://www.citeulike.org/user/InquilineKea/article/8980563 => Toward molecular design for hazard reduction—fundamental relationships between chemical properties and toxicity - this is a really recent (and readable) paper that shows a way to classify a chemical's potential toxicity based on its chemical structure. Summary at http://www.sciencenews.org/view/feature/id/70925/title/Better_by_Design

http://en.wikipedia.org/wiki/QSAR => QSAR model

http://www.jstor.org/stable/3433032 => very early system of classifying chemicals toxic to rodents

Case studies of particular toxins:

http://en.wikipedia.org/wiki/Ochratoxin
http://en.wikipedia.org/wiki/Tetrodotoxin => very important for neurophysiology research

More specific resources:
(I have many resources about amphetamine toxicity in particular, but I won't list them here for now)

http://www.longecity.org/forum/topic/47231-amphetamine-neurotoxicity-reductionprevention/ => very interesting discussion about research papers on amphetamine toxicity in particular (just be leery about the posts that advocate a particular consumption pathway).
 
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