What are the natural target of naturally occuring beta lactamase ?

  1. I have learned that beta-lactamase enzymes have very ancient origin. And they are just tinkered in the recent anthropogenic activity. So some original form must be out there. What are their natural target?
  2. jcsd
  3. Ygggdrasil

    Ygggdrasil 1,826
    Science Advisor

    Remember that penicillin was originally derived from a fungus. There are plenty of organisms in nature that produce antibiotic compounds from which the bacteria need to defend themselves.
  4. Actually I was looking for a specific example.
  5. bobze

    bobze 651
    Science Advisor
    Gold Member

    He was specific. Beta-lactamase attacks beta-lactam rings. Which forms the backbone of penicillins produced by fungi. Something bacteria would need to defend themselves against.

    If you are asking what was the specific fungi beta-lactam that bacteria evolved beta-lactamases to that is a silly question. Molecules don't fossilize so there is no reason we should expect to ever know the exact ancestral beta-lactam.
  6. Sorry you misunderstood me. I wanted to know the name of the species that produce such antibiotic , the bacteria that became resistant to that and the relationship between them. I am not looking for ancestral examples (may be an impossibility, who knows). I am looking for present cases where resistance developed (exist) for non-anthropogenic activity.
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