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What does HC3 mean in 'His HC3'?
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[QUOTE="Matt204823545, post: 6331675, member: 676846"] [B]TL;DR Summary:[/B] My lecturer said it means: 3rd residue, Cter to Helix 'H' but that makes no sense. My lecturer said it means: "3rd residue, C-terminal to Helix 'H'" but that makes no sense. If it's the 3rd residue then it can't be on the C-terminal, because the C-terminal is at the end of a massively long sequence of residues. Visa versa if it's on the C-terminal then it can't be the 3rd residue. I tried asking him but all I got in response was a lot of hand waving and "don't worry about this, just learn the overall picture blah blah blah". But that's unacceptable, I found something that doesn't make sense to me and I deserve an answer if I am paying hundreds of thousands of dollars. Googling turned up nothing. So I created an account here and am seeking your help. A little background: His HC3 is a Histidine residue and forms one of the most important salt bridges when oxygen is removed from hemoglobin, it stabilises the "T" state of Hb. His HC3 forms a salt bridge with Asp FG1 (FG1 meaning: "1st residue, in the loop between helices 'F' and 'G'" which thankfully makes sense!) [/QUOTE]
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