What does HC3 mean in 'His HC3'?

In summary, the conversation discusses a confusion about the meaning of "3rd residue, C-terminal to Helix 'H'". The speaker tried to clarify with their lecturer but only received a vague response. They then turned to the internet for answers and created an account to seek help. The conversation also provides background information on a Histidine residue and its role in stabilizing the "T" state of Hb through a salt bridge with Asp FG1. It is explained that helix H has directionality despite not occurring at the N- or C-terminus of the protein. The meaning of "3rd residue, C-terminal to Helix 'H'" is clarified as the third residue after the end of helix H when numbering
  • #1
Matt204823545
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TL;DR Summary
My lecturer said it means: 3rd residue, Cter to Helix 'H' but that makes no sense.
My lecturer said it means: "3rd residue, C-terminal to Helix 'H'" but that makes no sense. If it's the 3rd residue then it can't be on the C-terminal, because the C-terminal is at the end of a massively long sequence of residues. Visa versa if it's on the C-terminal then it can't be the 3rd residue.
I tried asking him but all I got in response was a lot of hand waving and "don't worry about this, just learn the overall picture blah blah blah". But that's unacceptable, I found something that doesn't make sense to me and I deserve an answer if I am paying hundreds of thousands of dollars.
Googling turned up nothing. So I created an account here and am seeking your help.

A little background: His HC3 is a Histidine residue and forms one of the most important salt bridges when oxygen is removed from hemoglobin, it stabilises the "T" state of Hb. His HC3 forms a salt bridge with Asp FG1 (FG1 meaning: "1st residue, in the loop between helices 'F' and 'G'" which thankfully makes sense!)
 
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  • #2
Even though helix H does not occur at the N-terminus or C-terminus of the protein, it still does have a directionality to it. The N-terminal end of the helix is closer in primary sequence to the N-terminus of the protein and the C-terminal end of the helix is closer in primary sequence to the C-terminus of the protein (in the same way we can talk about the 5' end of a gene and the 3' end of a gene, even if the gene occurs in the middle of a chromosome, far away from the actual 5' and 3' ends of the DNA molecule in which the gene resides). So, another way of saying "3rd residue, Cter to Helix 'H'" is the third residue after the end of helix H (when numbering residues from N-ter to C-ter as is conventional).
 
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1. What is HC3?

HC3 stands for "His HC3" and is likely a reference to a specific individual or organization.

2. Does HC3 stand for a specific organization or company?

It is unclear without more context. HC3 could potentially stand for a company or organization's name, but without more information it is impossible to determine.

3. Is HC3 a scientific term?

No, HC3 is not a commonly used scientific term. It is likely a reference to a person or organization.

4. Could HC3 stand for a medical condition or disease?

No, HC3 is not a known medical condition or disease. It is likely a reference to a person or organization.

5. Is HC3 an acronym?

It is possible that HC3 is an acronym, but without more context it is impossible to determine what it stands for. It could stand for a variety of things depending on the context in which it is used.

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