Inertia is defined as the resistance of an object to changes in its state of motion, often linked to mass. The term is ambiguous and can refer to various concepts like mass, momentum, or energy required for acceleration. Historical figures like Galileo, Newton, and Einstein have contributed to the understanding of inertia, with Einstein proposing that inertial mass and gravitational mass are equivalent. Mach's hypothesis suggests that inertia may arise from the mass of the universe, though this remains unproven. The discussion emphasizes the need for clarity in defining inertia and its implications in physics.