A comprehensive book recommended for high school students new to biology is "Life: The Science of Biology" by Sadava et al., which is suitable for introductory courses. Another strong option is "Essential Cell Biology" by Bruce Alberts et al., which is accessible to motivated students and requires no prior knowledge in biology. While "Campbell Biology" is often viewed as college-level material, some participants noted that it could also be manageable for high school students, particularly those in advanced placement courses. Overall, both Sadava's and Alberts' texts are considered appropriate for high school learners looking to grasp foundational biology concepts.