Welcome to the physics forums!
For starters I would like to clarify that what you refer to as "actual physics" is more commonly known as "classical physics", as quantum mechanics is (a huge) part of physics. (not to demean the classical physics, as it is still useful in many applications)
Now to address the question: One of the things that was sort of guessed, but is a very good and based guess, that particles obey wave mechanics. This is the point where a wave equation was needed to describe a particles. Once you introduce that, we imply that many of the behaviours of wave mechanics apply in particles small enough and light enough. One of them, that turns out to apply, is the uncertainty principle.
The uncertainty principle states that if we were to multiply the standard deviations (closely related to how spread out the wave function) of momentum and position they must always obey:
Δx*Δp≥ħ/2
where Δp, Δx are the standard deviations of momentum and position respectively.
In laymen's terms it basically means that should you at any point know the momentum with more certainty, you'll lose certainty over the position and vice versa. In the scales of quantum mechanics, it can mean huge changes on the certainty should one be spread out more or less.
Lesson here is, at no singular point can you be sure with 100% certainty that the particle is there. Otherwise it implies the particle went *everywhere in the universe* ever since you measured it. However, you could start bargaining with the universe. If you are completely fine with the particle be just in a certain region (say, 2<x<5), it is possible for you to make its wave function in space be in that region with near 100% success, and although it wouldn't sit quietly there (after all it has a not-exactly-zero momentum), you can be sure enough it'll stay around that region. It is done with changing the potential energy in space.
Indeed to get any further, math that is not normally taught in high school is involved, in particular Differential Equations and integrals, but with enough patience, good book and enough interest one could learn it.