For a simple (and useful) example for Minkowski spacetime, use "light-cone coordinates".
In my conventions, u\equiv t+x\qquad v\equiv t-x
and \hat u\equiv \frac{1}{2}\left( \hat t+\hat x \right)\qquad \hat v\equiv \frac{1}{2}\left( \hat t-\hat x \right).
where \hat{} indicates a basis vector (not necessarily a "unit-magnitude" vector).
(Other conventions use factors of \sqrt{2}.)
In my signature conventions, using the Minkowski-dot-product, \quad \hat t \cdot \hat t=1, \quad \hat x \cdot \hat x= -1, and \quad \hat t \cdot \hat x=0.
postscript:
Although the basis vectors \hat u and \hat v point along the light cone, and they may look to have a Euclidean-angle of "90-degrees" between them, these basis vectors are not Minkowski-orthogonal (which you can check by computing the Minkowski-dot-product).