Why can't adenine and cytosine pairs form?

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SUMMARY

Adenine and cytosine cannot form stable pairs due to the insufficient strength of hydrogen bonds between them. The shapes of adenine and cytosine do not complement each other effectively, resulting in fewer points of contact for bonding. In contrast, adenine pairs well with thymine (or uracil in RNA), which allows for a more stable bond due to better shape compatibility and increased hydrogen bonding. The discussion also touches on the significance of molecular replication, emphasizing that successful molecules must duplicate to proliferate in their environment.

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  • Understanding of hydrogen bonding in molecular biology
  • Familiarity with the structures of nucleobases: adenine, cytosine, thymine, and uracil
  • Basic knowledge of DNA replication processes
  • Concept of molecular stability and complementarity in biochemistry
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  • Research the structural differences between nucleobases and their impact on bonding
  • Study the role of hydrogen bonds in DNA stability
  • Learn about the mechanisms of DNA replication and its biological significance
  • Explore the concept of molecular evolution and the importance of replication in survival
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Students of molecular biology, biochemists, and anyone interested in understanding the principles of DNA structure and replication.

joejo
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hi I was curious Why can't adenine and cytosine pairs form? Like I know it doesn't happen but WHY?

thanks for your help guys and girls!
 
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joejo said:
hi I was curious Why can't adenine and cytosine pairs form? Like I know it doesn't happen but WHY?
It is not that they can't bond at all. It is just that the total bond strength is not very strong, so it is not stable. All bonds are hydrogen bonds, so to make a strong molecular bond there have to be many points of contact between points with opposite polarity. This will only occur if the shapes are complementary so that they fit together. The fact is that the shape of adenine and the shape of cytosine don't fit together very well. Thymine (or uracil in RNA) fit much better with adenine, providing many more points of hydrogen bonding and a much more stable bond.

AM
 
hey andrew,

thanks soo much its makes more sense now...because they are all constant at 2nm but then again there will be a lack of hydrogen bonding making the pair unstable...


my next ? is why is duplication important? is there any reason behind the importance of duplication/replication
 
joejo,

"is there any reason behind the importance of duplication/replication"

That depends on what makes something "improtant". Nature doesn't care one way or the other whether one of its processes involves the replication of extermely complex molecules. It just stumbled on to this system, and the result was living organisms (which it also doesn't give a hoot about). However, as living organisms ourselves, we tend to think that life IS important. And without replication there wouldn't be any.
 
true true...thanks jdavel...i thought there was something scientific behind its importance...is there?
 
joejo said:
my next ? is why is duplication important? is there any reason behind the importance of duplication/replication
Without the ability to duplicate, a successful molecule (ie. successful in surviving in its environment) would not proliferate. Successful molecules that duplicate themselves would proliferate. It is as simple as that.

AM
 
thanks guys! now i completely understand the importance of DNA
 

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