Controlled fission and fusion systems operate under different (and more constrained) conditions than uncontrolled (explosive) fission or fusion systems, which is analogous to difference between deflagration/combustion/burning vs explosion.
Uncontrolled fissile systems become prompt supercritical, and generated energy in microseconds, as opposed to controlled systems which operate normally in a critical state to maintain a constant/steady release of thermal energy. Typically, the material used in the process is highly enriched (fissile isotope) in the metal form.
In modern commercial fission reactors, about 5% or so of the initial uranium is consumed over a period of three to four years (depending on energy density). A typical fissile reaction rate is on the order of 1019 fissions/cm3-s
Similar in controlled fusion, the energy/reaction rate is constrained, and controlled fusion occurs at lower temperatures than are realized in thermonuclear weapons. The temperature (and energy density) is limited because the magnetic field strength and strength of structural materials are limited. Limits on magnetic field strength impose limits on the magnetic pressure that we can achieve in reactors.
Hybrid fusion/fission devices exploit the neutrons occurring from fission, but that then involves producing fission products, which require disposal as spent fuel or high level waste.