Zero, I agree fully that a materialist worldview is practical (and I will try to use only laymen's words in my posts -- thanks for the hint). Insofar it is quite reasonable.
Did the fight not start when some tried to think everything in materialist terms, i.e. not just specific aspects -- eg. tools, gadgets -- for which this perspective is adequate? For finding laws, the presently fashionable form of science operates by 'generalization'; so some feel that something successful in one realm should be applicable in other, and -- swoosh -- they generalize eg, the materialist approach. The trouble with the principle of generalization is that it can secure laws in a limited realm only, it can't secure strictly universal laws (eg. even the law of entropy is subject to entropy -- while there are universal laws: eg. the principle of truth is subject to truth).
So I don't think the problem is that people would not admit practical solutions to real problems, but that some refuse to accept the materialist position as the solution for everything. It is no coincidence, for example, that since the upsurge of materialism a new wave of ethics arose -- because knowing how to manipulate things does not warrant knowing about the context as a whole, into which all manipulations must fit.
The weakness in the materialist's viewpoint is in its wanting to handle material things while choosing a way of setting out that limits understanding the ultimate nature of material things. On this path, one can caclulate bits and pieces to an amazing degree, but not know what they are in their own right. On this path, one can't know what it is to be an electron, or a quark. Or mass / energy and information. We can depict such structures in many systems, and they make sense depending on the system. The crux shows fully with the aliveness of living beings. And while we can't say we have really understood the nature of the things -- not even of inert matter, for that matter -- the principle itself of approaching things in looking at them from outside limits the potential as such of this attempt. This approach seems to offer objectivity, but it is limited already because no empirical data can cover everything. Insofar, the idea that one day one will eg. be able to understand even difficult things such consciousness is not a secure idea. One can depict aspects of awareness to some extent, eg. in real time on a tomograph, but that is not the actual nature of awareness, it is only a picture of it. One may know what somebody is thinking about, but that does not improve human understanding. For getting along with each other, we don't need such gadgets. This does not exclude that some will believe what such gadgets show is the reality of their awareness, just as there are always some who robotize themselves, or believe they are in reality Napoleon. One can produce even collective beliefs (look at what the media are doing).
Some time ago there was debate on this thread about cultural dangers of the materialist viewpoint. You did not seem convinced that there is one, but I think if a culture were to rely only on this viewpoint, it would incur severe dangers, up to a moral decay. Look at how already small kids learn to kill off their emotional responsiveness by seeing everything only in terms of a manipulative control over things, up to cold killing that can be learned in video games. For sanity to be possible, there must be an overview. It is important that all this is the effect of conditioning. The interesting challenge is thus to find a world view that does not foster forms of disintegration, or impose a fundamentalist ideology, but allows to integrate properly all the -isms, letting all things 'fall into place'. That's my sort of work. I am trying to develop an approach that is not self-limited by assumptions. That's not just academic daydreaming, but also quite practical (even though it is not limited to the materialist stance). IMO this approach would allow also a better understanding even of the nature of material matter, and finally a better integration of the diverse physical theories (while not necessarily treading eg. the GUT path, which is still based on a 'look from outside'). To my sense, a physics is possible that integrates life fully.
But maybe I have not yet hit on the head the nail that you had in mind?