- #1
ambzrose
- 8
- 0
How do deadly chemicals like Cyanide, block the electron tranport sytem??
How does Cyanide block the electron transport system?
In summary, deadly chemicals like Cyanide can block the electron transport system by inhibiting oxygen consumption in the mitochondria. This can lead to a shutdown of the Krebs cycle and can be tested by observing its effects on bacteria that can ferment. Cyanide has a similar mechanism to Carbon Monoxide poisoning, but specifically targets an enzyme in the mitochondria. Treatment for Cyanide poisoning is available through the use of specific antidotes.
- #2
gumbythescientist
- 11
- 0
I don't really feel like explaining it right now but this link might be of some use
http://www.ruf.rice.edu/~bioslabs/s...s/when-did-mitochondria-evolve/"]mitochondria/mitopoisons.html[/url]
http://www.ruf.rice.edu/~bioslabs/s...s/when-did-mitochondria-evolve/"]mitochondria/mitopoisons.html[/url]
- #3
Renge Ishyo
- 282
- 1
Via the link above:
Well there you go. The driving force force for the electron transport chain in the mitochondria is the presence of oxygen at the end of the chain to accept the hydrogens/electrons. No oxygen, and the whole Krebs cycle shuts down (it is the same as if you are suffocating in that respect).
This can (and probably has been) tested by seeing if CN will still have the same effect on bacteria that can ferment (respiration without the need for oxygen) and that might indirectly affirm this, but I don't have any first hand knowledge of this sort of thing.
Well there you go. The driving force force for the electron transport chain in the mitochondria is the presence of oxygen at the end of the chain to accept the hydrogens/electrons. No oxygen, and the whole Krebs cycle shuts down (it is the same as if you are suffocating in that respect).
This can (and probably has been) tested by seeing if CN will still have the same effect on bacteria that can ferment (respiration without the need for oxygen) and that might indirectly affirm this, but I don't have any first hand knowledge of this sort of thing.
- #4
Ouabache
Science Advisor
Homework Helper
- 1,346
- 8
That reference mentions that it inhibits oxygen consumption and has something to do with cytochrome oxidase. I remember from biochem, that carbon monoxide has a stronger affinity to hemoglobin versus oxygen and competitively inhibits oxygen uptake.. I wonder how CN inhibits oxygen uptake? (time to go dig out my biochem book)
Last edited:
- #5
Renge Ishyo
- 282
- 1
This website offers a somewhat clearer statement of the mechanism involved, and even a treatment of sorts:
http://www.manbir-online.com/diseases/cyanide.htm
It seems like this is a similar idea to Carbon Monoxide poisioning (where it binds and inhibits the ability for Oxygen to bind), only this seems to take place with an enzyme specific to the mitochondria.
http://www.manbir-online.com/diseases/cyanide.htm
It seems like this is a similar idea to Carbon Monoxide poisioning (where it binds and inhibits the ability for Oxygen to bind), only this seems to take place with an enzyme specific to the mitochondria.
What is the Electron Transport System?
The Electron Transport System (ETS) is a series of biochemical reactions that occur in the inner mitochondrial membrane, responsible for generating the majority of ATP (adenosine triphosphate) in cells through oxidative phosphorylation.
What is the role of the Electron Transport System in cellular respiration?
The Electron Transport System is the final stage of cellular respiration, where high-energy electrons are transferred along a series of molecules to ultimately produce ATP. This process is essential for providing cells with the energy they need to carry out their functions.
What molecules are involved in the Electron Transport System?
The Electron Transport System involves several molecules, including NADH (nicotinamide adenine dinucleotide), FADH2 (flavin adenine dinucleotide), cytochromes, and coenzyme Q. These molecules act as carriers for high-energy electrons during the ETS process.
What is the importance of oxygen in the Electron Transport System?
Oxygen is the final electron acceptor in the Electron Transport System, meaning it is necessary for the process to continue. Without oxygen, the ETS cannot function properly, leading to a decrease in ATP production and potential cell damage.
How does the Electron Transport System contribute to metabolism and energy production?
The Electron Transport System plays a crucial role in metabolism and energy production by producing the majority of ATP in cells. This energy is used for various cellular processes, such as muscle contraction, nerve impulses, and maintenance of body temperature.
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