- #1
Pythagorean
Gold Member
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neat trick:
http://www.hhmi.org/bulletin/may2010/features/moves3.html
http://www.hhmi.org/bulletin/may2010/features/moves3.html
If ChR2 is a blue activator, halorhodopsin (NpHR) is a yellow silencer. It was discovered in Natronobacterium pharaonis, a bacterium isolated from a high-alkaline, high-salt lake in Egypt. In the bacterium, the light-driven NpHR channels pump chloride ions into the cell, a flow that ultimately helps drive the synthesis of ATP, the cell's biochemical fuel. Transferred into neurons, however, these channels respond to yellow light by hyperpolarizing the cells, effectively silencing them.