- #1
sameeralord
- 662
- 3
Hello everyone,
Aspirin(acetylsalicylic acid) is a weak acid. So in the acidic PH of stomach it must be more in nonionised form. In the alkaline PH of intestine it must be more in ionised form. Now my note says something is more absorbed if it is in non ionised form, this makes sense because lipid soluble substances can easily go through plasma membrane. But with asprin the absorption is actually more in the intestine. I can understand it is more soluble in intestine, but if it is ionised how can it go through plasma membrane of intestinal villi cells and reach portal circulation. Thanks
Aspirin(acetylsalicylic acid) is a weak acid. So in the acidic PH of stomach it must be more in nonionised form. In the alkaline PH of intestine it must be more in ionised form. Now my note says something is more absorbed if it is in non ionised form, this makes sense because lipid soluble substances can easily go through plasma membrane. But with asprin the absorption is actually more in the intestine. I can understand it is more soluble in intestine, but if it is ionised how can it go through plasma membrane of intestinal villi cells and reach portal circulation. Thanks