- #1
jolly_math
- 51
- 5
- Homework Statement
- Which of the following compounds can undergo Friedel-Crafts alkylation?
- Relevant Equations
- Friedel-Crafts alkylation
The answer is that the 2nd, 3rd and 6th compounds can undergo Friedel-Crafts alkylation.
I don't understand why the 4th compound cannot undergo a Friedel-Crafts alkylation reaction, but the 2nd compound can. It has an activating NH2 group and a weakly deactivating Br group, and it's similar to the 2nd compound which has an activating CH3 group and a weakly deactivating Cl group – what makes it different?
Thank you.