The conversion from a Fischer Projection to a Haworth or Chair Conformation involves rotating the molecule 90 degrees and then folding the molecule along the longest chain to form a ring. The horizontal lines in the Fischer Projection become bonds pointing down in the Haworth or Chair Conformation, while the vertical lines become bonds pointing up.
A Haworth or Chair Conformation provides a more accurate representation of the three-dimensional structure of a molecule, particularly for cyclic molecules. It also allows for easier visualization of the stereochemistry and potential interactions with other molecules.
Yes, a Fischer Projection and a Haworth or Chair Conformation can represent the same molecule. They are just different ways of depicting the same molecule in different orientations.
In a Fischer Projection, the carbon atoms are numbered based on their position in the longest chain, with the carbon closest to the functional group being assigned the lowest number. In a Haworth or Chair Conformation, the carbon atoms are numbered clockwise starting from the oxygen atom.
One limitation of using a Haworth or Chair Conformation is that it may not accurately depict the actual conformation of a molecule in solution. This is because the Haworth or Chair Conformation is a static representation and does not account for the flexibility and dynamic nature of molecules in solution. Additionally, the Haworth or Chair Conformation is primarily used for cyclic molecules and may not be suitable for representing linear molecules.
