What brain cells does glioblastoma affect?

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In summary, glioblastoma is a type of cancer that affects cells in the brain called glial cells. However, recent studies suggest that it could also originate from other types of cells such as astrocytes, oligodendrocyte progenitor cells, and neural stem cells. This cancer is known for being resistant to traditional treatments such as chemotherapy and radiation. Researchers have also identified the role of ion channels in the progression of glioblastoma. Further research is needed to understand the cellular origin and develop more effective treatments for this aggressive cancer.
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alantheastronomer
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Does glioblastoma, as the name suggests, affect only glial cells, or does it also impact neurons as well? Why does it spread so rapidly and effectively? And what modifications need to be done to the Zika virus to make it more effective at battling it?
 
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https://en.wikipedia.org/wiki/GlioblastomaThe link mentions astrocytes and neurones “The cellular origin of glioblastoma is unknown. Because of the similarities in immunostaining of glial cells and glioblastoma, it has long been assumed that gliomas such as glioblastoma originate from glial type cells. However more recent studies suggest that astrocytes, oligodendrocyte progenitor cells and neural stem cells could also serve as the cell of origin.”



Pretty resistant to chemo and radiotherapy from what I have read too.



Its an aggressive cancer and ion channels are mentioned in the link, the link below gives some more detail



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530825/
 

1. What are the main types of brain cells affected by glioblastoma?

The main types of brain cells affected by glioblastoma are astrocytes, oligodendrocytes, and ependymal cells. These cells are collectively known as glial cells, which provide support and protection for neurons in the brain.

2. How does glioblastoma affect astrocytes?

Glioblastoma affects astrocytes by causing them to grow and divide uncontrollably, leading to the formation of a tumor. This tumor can put pressure on surrounding brain tissue and disrupt normal brain function.

3. Can glioblastoma affect other types of brain cells?

Yes, glioblastoma can also affect oligodendrocytes and ependymal cells. However, astrocytes are the most commonly affected cells in this type of brain cancer.

4. What role do oligodendrocytes play in glioblastoma?

Oligodendrocytes are responsible for producing myelin, a fatty substance that insulates nerve cells and helps them transmit signals efficiently. In glioblastoma, these cells may become damaged or destroyed, leading to disruptions in nerve signaling.

5. Can ependymal cells be affected by glioblastoma even if they are not directly involved in tumor formation?

Yes, glioblastoma can indirectly affect ependymal cells by putting pressure on the spaces in the brain where they are located, called ventricles. This can lead to a buildup of cerebrospinal fluid and increased pressure in the brain, which can cause symptoms like headaches and nausea.

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