I understand that by up and down quark you mean up type quark (t,c,u) and down type quark ( b,s,d). The answer is yes.
The couplings of the W boson to any up type down type quark pair are described by the CKM matrix ( see http://pdg.lbl.gov/2014/reviews/rpp2014-rev-ckm-matrix.pdf for their...