A W boson can convert an up quark into a down quark within the same generation, as they are both first-generation quarks. The CKM matrix describes the probabilities of transitions between quark flavors, indicating that while transitions between up and down-type quarks are possible, they are not equally favored. Couplings to strange and bottom quarks are also possible, though less common. Energy and momentum conservation must be considered for certain processes, making some transitions, like W → tb, impossible. Resources for further understanding include the CKM matrix documentation available online.