Factorization of integers is crucial in a first number theory course as it underpins the understanding of prime numbers and their applications in cryptography, particularly in securing sensitive data online. It raises important questions about the efficiency of algorithms used to determine factors of large integers, which can significantly impact computational time. The discussion highlights the relevance of factorization in real-life scenarios, such as public key cryptography, which relies on the difficulty of factoring large numbers for security. Additionally, factorization is essential for solving quadratic equations, illustrating its mathematical importance. Overall, emphasizing these applications can effectively motivate students in their study of number theory.