Could a deficiency in somatostatin contribute to Chiari malformation?

[Medgirl314]

I came across and article about how the hormone somatostatin can affect intacranial hypertension. After reading this article, I researched the hormone. http://www.wisegeek.com/what-is-somatostatin.htm I found that somatostatin deficiencies can cause symptoms similar to those of Chiari malformation. Since somatostain is a growth hormone, could a deficiency conrtibute to the cause of Chiari? Could the reason that the tonsils extend too much be due to a smaller skull caused by a deficiency? I realize that it would be illogical to hypothesize that somatostatin causes Chiari and many disorders all on it's own, but could it be a contributing factor?

Thanks in advance for replies!

 

[Evo]

Sorry medgirl, but for links to substantiate medical claims, we only allow peer reviewed research from an approved journal. I've allowed one link that explains what the hormone is.

 

[Medgirl314]

Thanks for letting me know! Are you saying that guesses that have not been peer-reviewed aren't allowed, or that I can only use peer-reviewd links in my post?

 

[Evo]

Thanks for letting me know! Are you saying that guesses that have not been peer-reviewed aren't allowed, or that I can only use peer-reviewd links in my post?

Guesses aren't allowed, that is along the lines of a personal theory. You may ask questions as long as they are not leading.

 

[Medgirl314]

Okay, thank you!

 

[Medgirl314]

Cna I go back and edit it? I don't see an "edit" button.

 

[Evo]

Cna I go back and edit it? I don't see an "edit" button.

What do you want to edit? Just post it here, trust me, if it's not allowed, it will disappear.

You seem to want to do what's right, so I'll be glad to help.

 

[Pythagorean]

I've never heard of Chiari before (I've read about it since this thread) and I'm not a medical expert, but somatostatin is a really prevalent biomolecule. It inhibits growth hormone and growth hormone is everywhere. So could it contribute to malformations in bone? Probably. But I'm not sure how pervasive such a relationship would be, or how useful it would be to know since somatostatin is everywhere and Chiari (apparently) can be a symptom of many different illnesses.

 

[Evo]

Inhibiting growth hormone is just one function.. http://en.wikipedia.org/wiki/Somatostatin

 

[Pythagorean]

Most of the other functions probably aren't relevant to malformations in the cerebellum though; particularly not its gastrontestinal functions.

 

[Medgirl314]

Thanks for the replies! Evo, I was going to take out some of the links, but I think you did that for me. Thanks! Pythagorean, thanks for the replies! As far as I understand, Chiari isn't really a malformation of the cerebellum due to the size of the cerebellum, it's a malformation that is caused by the skull size. I haven't heard of Chiari being a symptom of different illnesses, only an (excuse the term) "illness" in itself, but it seems plausiable since it is often connected with other dieseases.