Annihilation of a proton and an antiproton releases energy equivalent to their combined mass, approximately 1.876 GeV, which is the sum of the rest mass energies of both particles. The process typically results in the emission of two photons, each carrying energy equal to the mass of one particle. If kinetic energy (KE) is added to the particles before annihilation, the total energy released increases accordingly, as energy is conserved. Comparatively, proton-antiproton annihilation releases about 143 times more energy than the proton-proton fusion process in the sun, which converts about 0.7% of mass into energy. The discussion also touches on the complexities of energy release in different reactions and the varying outcomes based on interaction conditions.