aheight said:
The Phase-3 results are irrefutably hard-empirical-data.
Yes, but.
A trial of 30,000-40,000 people can detect problems at the 10
-4 level. Twice as many people in the trial, and you are a factor of 2 more sensitive. So zero bad reactions in a trial of this size means fewer than 30000 to 35000 bad reactions in the US as a whole if everybody is vaccinated. That's less than 10% of the current Covid integrated fatalities.
Odds not good enough? Nothing says one needs to claw one's way to the head of the line. If a million people go first, and they do not show any bad reactions, your sensitivity is about 3 x 10
-6 level, or about 1000 bad reactions. This is less likely than going to the ER because of a pogo-stick injury.
Still not good enough? Let ten million people - still only 3% of the population - go ahead of you. Now the sensitivity is 3 x 10
-7, and we can be sure there will be fewer than 100 bad reactions. This is less likely than being struck by lightning.
Still not good enough? Let 100 million people go ahead of you - you're still in the front half of the line. Now the sensitivity is 3 x 10
-8, and we can be sure there will be fewer than 10 bad reactions. This is less likely than becoming President.