Are Moderna/Pfizer/JJ/AZ using the same code for the spike?

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Discussion Overview

The discussion revolves around whether the Moderna, Pfizer, Johnson & Johnson, and AstraZeneca vaccines utilize the same genetic code to produce the spike protein of the coronavirus. Participants explore the similarities and differences in the spike proteins generated by these vaccines, considering the implications of viral variants.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • One participant questions if the spike protein produced by the body is identical across the four vaccines.
  • Another participant suggests that Moderna, Pfizer, and Johnson & Johnson may be using effectively the same spike protein based on research from Jason McLellan's group.
  • A different participant recalls a program indicating that early researchers shared information about the spike protein with Moderna and Pfizer.
  • There is uncertainty expressed about whether the genetic codes used in the vaccines are exactly the same.
  • A post includes a recommendation regarding the pause of the Johnson & Johnson vaccine due to safety concerns, which may not directly relate to the spike protein discussion but adds context to the conversation about vaccine safety.

Areas of Agreement / Disagreement

Participants express differing views on whether the genetic codes for the spike proteins are identical, indicating that the discussion remains unresolved with multiple competing perspectives.

Contextual Notes

Some statements rely on specific research findings and may depend on definitions of "identical" in the context of genetic coding. The discussion does not clarify the extent to which the spike proteins may differ among the vaccines.

brajesh
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TL;DR
Are Moderna/Pfizer/JJ using the same genetic code to make the spike?
Given the variants of the corona virus now appearing, I was wondering,

Are Moderna, Pfizer and Johnson and Johnson and Astrazeneca all using the same genetic code to create the spike protein?
Or more specifically, the spike protein that's made by our body, is it the identical spike protein in all these four vaccines?

I hope this question makes sense?
 
Biology news on Phys.org
I'm not sure whether the genetic codes used are exactly the same, but for Pfizer, Moderna, and J&J they should be effectively the same as they are based on a prefusion stabilized, membrane-anchored SARS-CoV-2 full-length spike protein from Jason McLellan's group at UT Austin.

https://news.utexas.edu/2020/02/19/...results-in-new-map-to-support-vaccine-design/
https://science.sciencemag.org/content/367/6483/1260

https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 (Pfizer/BioNTech)
https://www.nejm.org/doi/full/10.1056/nejmoa2022483 (Moderna)
https://www.nationalgeographic.com/...s-solving-puzzle-yielded-coronavirus-vaccines (Pfizer, Moderna, Novavax, Johnson & Johnson)
 
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Likes   Reactions: pinball1970, EPR, brajesh and 1 other person
Recommendation to Pause Use of Johnson & Johnson’s Janssen COVID-19 Vaccine
Updated Apr. 20, 2021
Print
What you need to know:
The use of Johnson & Johnson’s Janssen (J&J/Janssen) COVID-19 Vaccine is paused for now. This is because the safety systems that make sure vaccines are safe received a small number of reports of people who got this vaccine experiencing a rare and severe type of blood clot with low platelets.
Seek medical care right away if you develop any of the symptoms below.
If you have any questions at all, call your doctor, nurse, or clinic.
[ . . .]
###
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/JJUpdate.html
 

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