Axoneme Beat: Regulation of Dynein Motor Activity

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The discussion revolves around the coordination of dynein motors in axonemes, particularly in the context of ciliary and flagellar beating. The initial inquiry focuses on the accuracy of a brief description of oscillating instabilities in axonemes, where dyneins can detach from filaments, leading to a domino effect that generates oscillatory motion due to microtubule elasticity. The conversation confirms that the concept applies to both ciliary and flagellar mechanisms, despite differences in their undulation. References to the sliding filament model and specific studies, such as those by Dillon and Fauci, highlight the complexity of synthesizing existing literature on the subject, indicating a need for clarity in understanding the mechanisms involved in ciliary beating.
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Hey there,

I've been trying to get my head around how the dynein motors in it are coordinated, and I was wondering if this extremely brief paragraph was accurate? It's just intended to be an 'here's the toe I put in the terrifying waters of actual papers' bit for an essay.

An axoneme can undergo ‘oscillating instabilities’, in which an oscillating state occurs when it is no longer stable to maintain a non-oscillating state because of a change in the parameters of the system. For example, a group of dyneins may suddenly lose contact with the filament due to an initial few motors losing contact and inducing a domino-effect. When this mass-detachment of dyneins is followed by another build-up of force, oscillatory motion is generated, because of the elasticity of the microtubules. Current study points to the beat of the axoneme itself as a regulatory mechanism for dynein activity.

Thanks,
 
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Are you referring to ciliary/flagellar beating?
 
Yes:)

I know their undulation mechanisms are different, but this idea still applies to both of them no?
 
I'm vaguely familiar with the 'sliding filament model', and work by Dillon and Fauci on modeling ciliary beating here:

Dillon, R. and Fauci, L.J., An integrative model of internal axoneme mechanics and external fluid dynamics in ciliary beating. J. Theor. Biol. v207. 415-430.

I'm having trouble understanding the context of your question. Are there specific papers/results you are reviewing? The literature is rather extensive and it is difficult (for me) to synthesize a coherent picture.
 

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