Can a Portable Biochemical Testing Device Revolutionize Disease Management?

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The discussion centers on the potential for developing a convenient device for real-time testing of various hormones and biochemicals in the body, similar to existing insulin testing devices for diabetics. The focus is particularly on thyroid hormones T3 and T4, highlighting their importance for individuals with thyroid disease. The feasibility of creating such a device is linked to the complexity of the molecules involved. A suggested approach for measuring biomolecule concentration includes using infrared, visual, or ultraviolet absorption techniques, applying the Beer-Lambert law or empirical absorption-concentration curves. Key challenges include identifying unique absorption/emission lines for target compounds and ensuring that other compounds do not interfere with the measurements. Additionally, using reagents that bind to specific molecules to create distinct signals is proposed as a potential solution.
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Hi all, I was thinking recently about insulin testing, and whether the convenience could be extended to other hormones and biochemicals in the body. For instance the thyroid molecules T3 and T4. It seems like a device capable of testing for the level of these molecules on the fly would be extremely useful for people with thyroid disease, and other tests may prove useful for other diseases as well.

My question is, how easy would it be to create a device, similar to what diabetics use, that could test for a large array of compounds in human blood and return their concentration?
 
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Well the difficulty depends on the molecule I suppose.

The simplest and cheapest way to determine the concentration of a biomolecule would have to be measuring IR/visual/UV absorption (or emissions) for some characteristic wavelength and use your basic Beer-Lambert law (or perhaps better, an empirical absorption-concentration curve).

The question there would be if you can identify an absorption/emission line unique to your target compound. (or at the very least, that the other compounds contributing to the absorption/emission would have relatively constant concentrations) Or you could find a reagent which, when added, would bind to your target molecule and create a characteristic line.
 
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