No, that is not always the case. There are a couple of general conditions:
1. Usually there is a conserved quantity; in that limited basis you could say that x1+x2 sum to something that is a constant.
2. A pair of particles with known/definite property values will not be entangled on that basis. So x1 and x2 cannot be definite prior to measurement.
So a typical system of 2 particles will, if prepared reasonably, meet condition 1. But it won't meet condition 2 unless you make non-commuting measurements on both. And then it will meet condition 2 but no longer will meet condition 1 (because the values are indefinite and the sum is not a constant).
On the other hand: entangled pairs meet both requirements, and generally any pair of particles that meets those requirements are entangled on that basis. I am sure there are specific exceptions, hopefully you get the idea.