Coulomb's law applies to point-charges. If the clumps are small, and the distance between them is much larger than their size, then it is a very good approximation to consider the clumps as point-charges.
Otherwise, you can proceed in two ways. If the charges in the clumps are themselves point charges, you can apply Coulomb's law to each pair of charges (one in one clump, one in the other), and add the results. If the charges are in a continuous distribution, you have to use integral calculus to perform the addition.
In three dimensions, you have to use vectors, because force is a vector quantity (magnitude and direction). $$\vec F = k \frac {q_1 q_2} {r_{12}^2}\hat r_{12}$$ where r12 is the distance between q1 and q2 and ##\hat r## is unit vector that points in the direction from q1 to q2.