COVID COVID-19 Coronavirus Containment Efforts

AI Thread Summary
Containment efforts for the COVID-19 Coronavirus are facing significant challenges, with experts suggesting that it may no longer be feasible to prevent its global spread. The virus has a mortality rate of approximately 2-3%, which could lead to a substantial increase in deaths if it becomes as widespread as the flu. Current data indicates around 6,000 cases, with low mortality rates in areas with good healthcare. Vaccine development is underway, but it is unlikely to be ready in time for the current outbreak, highlighting the urgency of the situation. As the outbreak evolves, the healthcare system may face considerable strain, underscoring the need for continued monitoring and response efforts.
  • #3,651
russ_watters said:
But the real problem with the article's analysis is that it lacks the word "debt".

Yes in Aus we are keeping Covid under control, and the economy is not doing horribly bad (just bad) by means of large amounts of debt. It looked like we heading to recovering and starting to pay off some of the debt, but then things got really bad in Victoria, but I will do a separate post about that. Where I am in Queensland the boarders just opened and tourists by the ton are arriving - that will help the economy enormously - but police etc must really be on watch for any rule breaking - already quite a few have been reported. Of course Queensland has a lot of income from mining which helped both Queensland and Australia's debt situation. Still it is expected we will have about a Trillion in debt when this is over. There is one small consolation - Queensland's Public Service was becoming really bloated - this has forced some downsizing - but in a responsible way. We had one premier who did it in one big hit and got walloped at the next election.

The question is debt or lives. I choose lives - debt, especially at our current low interest rates, can be paid back - a life never can.

Thanks
Bill
 
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  • #3,652
For the latest on the second wave we have in Victoria Australia caused by the security guards very lax behaviour in the hotel where overseas arrivals were quarantined:
https://www.couriermail.com.au/news/national/virus-outbreak-at-altaqwa-college-linked-to-covid19-crisis-at-public-housing-towers/news-story/8ef515f5602ffac7da8160ee31f1d506?utm_source=CourierMail&utm_medium=Email&utm_campaign=Editorial&utm_content=CM_BREAKING_CUR_02&net_sub_id=311202432&type=curated&position=1&overallPos=1

I know we do not discuss politics here but the Premier is doing every trick in the book to avoid taking responsibility. For example he set up an enquiry into the security guard situation. Everyone knows what happened, it was caused by the police union contacting him and saying we are not babysitters - get someone else to do it. When reporters call him to account - no comment - it's under investigation. I am afraid that would not work with me - I would call out the obvious tactic in front of the Premier and demand he explain himself. But for some reason they do not. Interestingly on the few occasions I have seen those type of tactics not 'accepted' by reporters, it always ends badly for the politician.

Thanks
Bill
 
  • #3,653
bhobba said:
The question is debt or lives. I choose...
You chose the question.
 
  • #3,654
russ_watters said:
These statements variously contradict each other and/or your prior statement, alternating between it is and isn't acceptable to not consider the economics, by adding or not adding a delay. Either you are taking into account the long-term impacts *now* - when you make the decision - or you aren't. If you are taking them into account *later*, then you aren't taking them into account *now*, at the time the decision is made. In my opinion, that's foolish, and never a good idea.

Perhaps I wasn't clear about what I was trying to communicate earlier, so let me rephrase it this way.

What I was trying to argue was that in a middle of an emergency, there is a trade-off between rapid action with potentially serious costs in the long-term, versus no action with immediate costs. In such a scenario, I would choose the rapid action to mitigate the immediate costs, while being aware of what could be the potential long-term costs. There is nothing contradictory about this at all, and frankly I find it puzzling why this would be at all a controversial point.

So let's try putting some numbers to it based on the current scenario for the USA vs a hypothetical no-response scenario:

Without shutdown, worst case (USA):
50% infection rate
2wk ave loss of work (that's probably high due to a near 50% asymptomatic rate)
80% of workers have paid sick leave/vacation
1 yr
=0.4% lost production/income/GDP (that's the employment impact on GDP only)

With shutdown and assuming effectively zero infection rate:
13% unemployment for 3 months (so far) vs 3.5% in Feb.
Annualized, that's 2.4% lost production/income/GDP

You may notice I didn't include deaths. 75% of deaths are in people who aren't part of the production economy (they are retired). And 100% of people who die are not included in per capita GDP anymore. So while total GDP could be lower by 0.125% ongoing (at a 1% death vs infection rate), the per capita GDP/income in a country should go up due to COVID deaths.

I also didn't include the cost of hospitalization. While hospitalization is a high personal cost, it isn't necessarily a high societal cost; it is a transfer. Hospitals/doctors/nurses make more money when more people are hospitalized.

I also didn't include the cost of government stimulus, since the "with shutdown" case is actually the true US outcome, which would have been worse without the stimulus, and the cost is in the trillions of USD. In other words, the damage of the shutdown is substantially worse than what I've been able to capture. The cost of the stimulus -- the delayed harm -- is substantially larger than 2.4% of GDP. But beyond saying "trillions" I haven't had much luck finding projections for the cost.

The hypothetical costs you outline above for an unchecked pandemic are flawed in several ways:

1. First, to achieve herd immunity in the absence of a vaccine will require that about 60-70% of the population will need to have been exposed or infected with SARS-COV2 (the virus that causes COVID-19). So the 50% infection rate you specify is an underestimate.

2. I'm assuming that the 2 week average loss of work is taken from the rough period of recovery from COVID-19. But you are not taking into account the wide variability in recovery time, given that some (if not many) patients who have "recovered" from COVID-19 (i.e. those who are no longer infectious) continue to exhibit symptoms for weeks or months after they cease to be infectious. In fact, there have been reports of COVID-19 patients who have experienced respiratory, cardiovascular, and (in some cases) neurological damage. These patients will require far more than 2 weeks to be able to fully recover from these serious symptoms, which will prolong their recovery period and will impact work productivity, costs of rehabilitation, etc.

3. You quote a 50% asymptomatic rate. I'm not sure where you pulled this number from, since as far as I know, there is still no good estimate of the actual asymptomatic rate for COVID-19 (I've heard quotes from 25%, but not sure what the latest data).

4. You also fail to take into account that the loss of GDP isn't based solely on loss of productivity from people getting sick. An unchecked pandemic will also spark fear and anxiety in the wider population (afraid of contracting the illness), which can manifest itself in many ways, including loss of spending in areas like, say, restaurants, bars, etc. So the loss in GDP will extend far beyond what you had estimated earlier.

5. You state above that hospitalization is not a societal cost but a transfer. At an individual level, perhaps that is true, but what you fail to take into account is what happens when hospitals are overburdened with a flood of COVID-19 cases (as what happened in Italy). In such a scenario, we have seen where doctors and nurses are forced to triage patients to determine who lives or dies due to lack of beds, resources, etc., leading to many people dying that could have been saved. In addition, people suffering serious medical conditions are no longer able to have medical provided due to all resources being tied up with COVID-19 cases. This has a clear societal cost, in terms of greater death, but also in loss of productivity due to a substantial number of these people being unable to work, etc.

6. You mention the cost of the stimulus due to the shutdowns. I acknowledge that this is costly, but again, if the economy is severely impacted due to an unchecked pandemic, I would argue the government will eventually have to carry out some form of stimulus anyways. So shutdown or not, any such scenario would have been equally costly. At least if the US had an effective quarantine and lockdown, followed by appropriate and effective testing and contact tracing and widespread mask-wearing (as has finally emerged in Canada), then the US would have been able to re-open their economies to mitigate the effects of the shutdown.
Then I have no idea what point you are trying to make as pertains to what I said. Of course every recession has a recovery. So what? Nor does it seem in alignment with your prior statement, which seemed pretty clear-cut that it was the harm in the recession that could be undone retroactively: "essentially wipe out the past damage and reduce or eliminate the debt accumulated during the pandemic."

So I'll say it again, perhaps in a different way: Debt is future economic harm endured for the purpose of mitigating present economic harm.

The point I was making is that as the economy recovers, then governments will be able to pay down or off the debt they have accumulated to mitigate the present economic harm. I don't see why this is at all hard to understand -- if I borrow money now with the promise I will pay back that money later, and I've saved enough money from my new job to pay off that debt, then the harm of my being indebted disappears.

I'm speaking of course of the South Korean compulsory digital/automated mitigation model. Denmark was highly lauded in the article vs Sweden, but Denmark has so far endured twenty times as many deaths per capita with a shutdown than South Korea has had without a shutdown.

South Korea was able to have a compulsory digital/automated mitigation model largely because that country (along with many other Asian countries e.g. Taiwan) was severely impacted by the 2003 SARS outbreak, and learned from that important lesson to invest heavily in public health measures.

Western countries like the US did no such thing, and have thus suffered the consequences of this. Hence the need for lockdowns, etc. Perhaps a lesson for future pandemics (which will no doubt occur).
 
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  • #3,655
russ_watters said:
You chose the question.

Fair enough - propose another.

Thanks
Bill
 
  • #3,656
russ_watters said:
Fair enough, but yeah, I'm not sure that's the same thing.
At least in Germany, it is very similar. Employed peopled are supported by exactly the same mechanism as during the last financial crisis (the one I linked to). There are additional measures which weren't taken back then (direct monetary help for self-employed people, easier access to unemployment benefits, consumer tax cuts).

russ_watters said:
But still, I would expect people impacted by that policy aren't counted as "unemployed", so that could explain some of the reason for the USA's much steeper "unemployment" numbers vs Europe during this crisis.
I agree with your basic point that it's difficult to compare countries right now because of differences in government spending. That's why I suggested to use the last financial crisis as a test case and compare how countries, which used policies like the one I linked to, did compared to countries which didn't use such policies. If I find the time, I'll look into this.

The difference between spening a lot now in order to give people financial security and spending little now are second-order effects. Sick people going to work because of fear of losing their jobs probably prolongs the endemic and increases its costs. Sound businesses going bankrupt is also a net negative; on the other hand government spending might subsidize bad businesses.
 
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  • #3,657
bhobba said:
Fair enough - propose another.
Death or undefined privacy risk?
 
  • #3,658
russ_watters said:
Death or undefined privacy risk?
Could you elaborate on the second part? Do you have successful examples in mind (like the digital part of China's strategy?) or are you speaking hypothetically? Do you include mandatory apps?
 
  • #3,659
russ_watters said:
Death or undefined privacy risk?

Sure - analyse it through that paradigm if you like. Ultimately in a democracy the people decide. Privacy is a concern here in Aus - but as possible death comes more to the fore privacy recedes somewhat. For example people are now saying, including even me, fine and arrest those just exercising their privacy to protect the rest of us. An example is those refusing to take Covid tests. That is their legal right, but the push now is, not to take away that privacy, but to fine and force them into lockdown in a hotel at their own expense. Actually the government through biosecurity legislation can force them to take the test, but do not want to go that far - yet.

Thanks
Bill
 
  • #3,660
kith said:
Could you elaborate on the second part? Do you have successful examples in mind (like the digital part of China's strategy?) or are you speaking hypothetically? Do you include mandatory apps?
Yes, I'm talking about South Korea.
 
  • #3,661
Vanadium 50 said:
You know what makes me angry? Why is it worth trillions of dollars to mitigate Covid and not 0.1% as much to end malaria (which kills a million or two people a year)? I'll tell you why. People who get malaria are poor, black and brown and live far away. Important people get Covid. Rich people. White people. New Yorkers and others living in the rich part of the US.

The rich countries have developed a simple, cheap and available treatment for malaria. The bigger question in my mind is why those in power in the endemic regions are not concerned enough to overcome their differences in order to prevent millions of their own people, mainly children, from dying from an easily treatable disease? It is not rich, white New Yorkers who are preventing poor African children from getting the care they need.
 
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  • #3,662
bob012345 said:
The rich countries have developed a simple, cheap and available treatment for malaria. The bigger question in my mind is why those in power in the endemic regions are not concerned enough to overcome their differences in order to prevent millions of their own people, mainly children, from dying from an easily treatable disease? It is not rich, white New Yorkers who are preventing poor African children from getting the care they need.

Well when times are economically not so good, like here in Aus, the farmers, decimated by drought and fires, complain why are you spending money overseas and not helping them? Of course you can do both, but there is a limit to the tax you can impose before people vote you out - even the fear you will increase their cost of living is enough to generate a voter backlash. That's how the current government in Aus remained in power. The opposition were a shoe in according to polls. But close to the election it became obvious they had not fully costed many of their policies. Fear their wallets would be arbitrarily hit caused the average Australian to change their mind, and the Government had a surprise victory. Also it must be mentioned the bulk of a countries money comes from the middle and upper middle class - not the rich. There are many avenues open they take advantage of to reduce the tax they pay. I remember they had an inquiry into it and one of our richest citizens, Kerry Packer, was 'scolded' by a parliamentary committee for not paying what they thought was his fair share of tax. He was straight to the point - anyone that doesn't use any legal means to reduce his/her tax as much as possible is a 'mug', because to be blunt you (meaning the government) are not spending it wisely at all. He was applauded by the majority of Australians.

On a positive note Bill Gates is working hard to eliminate Malaria.

Added Later:
Of course it's not the rich in developed countries that is the problem, it's simple economics. That means, despite how terrible they feel about the blight of Malaria etc in the poor countries (and generally they do) you can't rely on those countries to help you out - they have their own issues.

Thanks
Bill
 
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  • #3,663
russ_watters said:
Death or undefined privacy risk?

It's not clear the apps work without traditional contact tracing and quarantine of confirmed cases and close contacts. If traditional contact tracing is in place, then it may be possible that the app need not be compulsory. Thus for example, it appears that the contact tracing for some of the early cases in the US was very well done. Another approach is to scale that up considerably (which one may need to anyway, even if there is an app).
 
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  • #3,664
From our local newspaper

ADELAIDE VACCINE TO TARGET HOT SPOTS

Residents living in Coronavirus hot spots in Melbourne may be targeted for human trials of an Australian vaccine in a plan being drawn up by an Adelaide scientist.

A COVID-19 vaccine developed by Flinders University professor Nikolai Petrovsky is the first Australian candidate to enter phase 1 human trials, The Australian reports.

Professor Petrovsky wants to conduct the next phase of human trials in Victorian outbreak hot spots.

“What we’re proposing is that if a vaccine is available that has passed initial safety and immunogenicity preliminary testing criteria in humans, that vaccine could be used in the context of a localised outbreak to see whether that breaks the cycle of virus transmission and actually brings the outbreak to a stop,” Professor Petrovsky, the founder of the South Australian biotech Vaccine, said.

“As soon as the phase 1 safety data is available there is no reason that our vaccine could not be used in an experimental setting by Victoria in just such a manner.”'

The UQ vaccine has also entered phase 1 trials. It may also be deployed when that is finished.

My dinner is getting cold, but IMHO this is really important. Will be able to discuss it a bit later.

Thanks
Bill
 
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  • #3,665
atyy said:
It's not clear the apps work without traditional contact tracing and quarantine of confirmed cases and close contacts.

I read where in the outbreak in Melbourne our app, called COVIDSafe, resulted in just one person traced. Why is not known at this stage eg most phones may have been turned off.

Thanks
Bill
 
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  • #3,666
https://www.jstor.org/stable/30082047?seq=8#metadata_info_tab_contents
Check the date of the study :wink:
 
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  • #3,667
Rive said:
https://www.jstor.org/stable/30082047?seq=8#metadata_info_tab_contents
Check the date of the study :wink:

Good one.

Thanks
Bill
 
  • #3,668
I've said this before, but the combination of "dying of Covid is even worse than dying of something else" and "all vaccines are perfectly safe - who are you anyway? Jenny McCarthy?" is leading us towards some real risks once there is a putative vaccine.

I'm going to take Victoria as an example. It has 6M people (a little more) and 24 deaths from Covid. Assuming you vaccinate everyone, and want the vaccine to kill fewer people than the disease, it needs to kill fewer than 4 x 10-6 of the people who receive it. To know that requires testing around a million people. (And few per million serious adverse effects is in the ballpark of common vaccines)

This is well above the size of any previous trial.

You can make the same argument for other vaccines, but this history in most cases was that there were years between development and widespread use and tests went from the few, to the few thousands, to monitored widespread use, to widespread use. The world wants to skip all that.
 
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  • #3,669
Yes - all true.

Those vaccinated to try and bring second wave outbreaks under control will be as part of the stage two trials (after stage 1 safety trials completed), and I highly doubt it will be anything but voluntary.

But it is a valid point - there is risk here without doubt - is the risk of deploying a vaccine whose medium/long term safety (short term safety is checked in stage 1) is unknown greater than the death rate of not deploying it? It's a very difficult ethical question. I have my view - if ever we want to get back to normal that, or something similar (ie an effective treatment), is virtually the only way. We could do something like have rather nice, distanced, and carefully protected communities for those at greater risk and let the rest go for it, achieve heard immunity and be done with it. But remember that heard immunity will have to be rather high because of how contagious it is, with an r0 about 2.3 or maybe even as high as 3. We can also have various mixtures of this.

That sets the scene - how should we proceed. Or is there another choice I have not considered.

Thanks
Bill
 
  • #3,670
Vanadium 50 said:
I've said this before, but the combination of "dying of Covid is even worse than dying of something else" and "all vaccines are perfectly safe - who are you anyway? Jenny McCarthy?" is leading us towards some real risks once there is a putative vaccine.

I'm going to take Victoria as an example. It has 6M people (a little more) and 24 deaths from Covid. Assuming you vaccinate everyone, and want the vaccine to kill fewer people than the disease, it needs to kill fewer than 4 x 10-6 of the people who receive it. To know that requires testing around a million people. (And few per million serious adverse effects is in the ballpark of common vaccines)

This is well above the size of any previous trial.

You can make the same argument for other vaccines, but this history in most cases was that there were years between development and widespread use and tests went from the few, to the few thousands, to monitored widespread use, to widespread use. The world wants to skip all that.

The logic here is laughably bad. Do you expect 24 deaths to be the final death toll from COVID-19 in Victoria? Given estimates of the IFR ~ 0.5-1% and a herd immunity threshold of 50-80%, the vaccine would potentially be preventing 15,000-48,000 deaths in the 6M population, so it would need to kill fewer than 2.5x10-3 of those who receive it (to cause fewer deaths than an unchecked COVID-19 outbreak), an estimate three orders of magnitude smaller than your estimate.

Furthermore, your cost benefit analysis does not take into account the costs of keeping the death toll to only 24 deaths (lockdowns and serious suppression of economic activity and personal freedom). An effective vaccine would enable lifting of lockdowns and returns to more normal levels of economic activity and personal freedoms.

I agree with the general point that we need to be careful in testing and evaluating a COVID-19 vaccine (especially to avoid political pressure causing a pre-mature release of the vaccine), but your argument here is very flawed.
 
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  • #3,671
Hey guys, this is very interesting. But remember what is being looked at is part of normal phase 2 testing using it to break hotspots so they are bought under control. At this stage Australia is not looking at mass vaccinations of the entire population, although I think it will eventually come.

Interesting as well the person responsible for the Adelaide vaccine thinks vaccines like the Oxford one they are looking at 2 billion doses by September will likely not end up the answer:
https://www.hospitalhealth.com.au/c...id-19-says-professor-1538816326#axzz6RzyX3U5F

If it's weak enough not to cause side effects it's effectiveness may be of value, but not enough for things to return to normal.

Thanks
Bill
 
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  • #3,672
bhobba said:
It's a very difficult ethical question.

One rational path forward is to let individuals decide based on their own risk.

I estimate my own risk of dying at around 10-5. I am substantially younger than the highest risk group, I am in an area that has below-average infections, and I am better able to isolate than others. So rationally, I should get vaccinated when ~105 others have demonstrated its safety. Some would even argue that I should "wait my turn."

Yggdrasil's argument that the numbers might change is in fact covered by this. If I moved to Victoria, the 10-5 goes down, and it is in my interest to go farther back in line. If I moved to Sao Paolo, the 10-5 goes up, and it is in my interest to go farther up in line. If there is a breakout a city or two over, the10-5 again goes up, and it is in my interest to go farther up in line.

The real problem is "who wants to be in the first few thousand?" If the answer is "nobody" (which could be entirely rational) something must be done. Most likely the answer will be "test it out on the poor". Nobody will say, that, of course, but if we said a barely-tested vaccine were a requirement to resume work for the "inessentials", well, we know who our guinea pigs pioneers will be. The fact that this is a group that is poorer, less politically powerful and frankly, less white than the population as a whole is just a sad side effect. Jonathan Swift would be proud.

The next problem is one we see today with other vaccines, like MMR, and that's freeloading. An effective vaccine reduces risk, and that in turn moves the rational equilibrium point further back. It is rational for each individual to let the others take on the risk, but if everyone does that, there is no risk reduction. This is an example of the Tragedy of the Commons. The freeloaders in the US are more educated, more urban, have higher incomes and are whiter than the population as a whole. A related issue is that the inevitably opens up the question "if I can choose for myself for Covid, why can't I with MMR?"
 
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  • #3,673
Vanadium 50 said:
One rational path forward is to let individuals decide based on their own risk.

In a democracy that is exactly how it is done. The use of the vaccine will be voluntary. But it's easy to guess what the average person will do. They will take it to avoid possibly spending longer in lockdown. Thats exactly what's happening with Covid tests. We can't force anyone to take them (there is a caveat if the biosecurity act is invoked - but the government, correctly IMHO, will only do that in a dire emergency) but if you refuse it, its off to quarantine at your own expense. When that rule was bought in not too many refused anymore.

I have chatted with anti-vaccer's about this. They were really worried about being forced to be vaccinated. I explained it is possible that will happen in a dire emergency, but is not likely. They were still worried - but the bottom line is, sometimes doctors must make decisions to save many lives that violate individual freedoms. It's a terrible decision, but laws are correctly on the books for an emergency. Of course they too are subject to the democratic process.

Interestingly here in Brisbane the phase 1 volunteers for the UQ vaccine had many many more people wanting to participate than required. Other factors than your rational self interest come into it such as can you live with yourself knowing you could help many others by taking some risk. There are, and have always been, people like that. Why I leave to philosophers, psychologists and sociologists. I would do it because that's how I was raised - that mateship is central to our culture - you can't let your mates down.

Thanks
Bill
 
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  • #3,674
Vanadium 50 said:
A related issue is that the inevitably opens up the question "if I can choose for myself for Covid, why can't I with MMR?"

The strength of evidence supporting mandatory vaccination is different for COVID-19 and for MMR. I hope we are get lucky, but it might already be optimistic to think the first COVID-19 vaccines will be as effective for COVID-19 as flu vaccines are for flu. For the flu vaccine, there seems to be debate about making it mandatory for various groups of people.

https://www.bmj.com/bmj/section-pdf/749788?path=/bmj/347/7933/Head_to_Head.full.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468130/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468124/
https://www.cdc.gov/flu/professionals/healthcareworkers.htm
 
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  • #3,675
Vanadium 50 said:
The real problem is "who wants to be in the first few thousand?"
This is a solved problem. They have found thousands of volunteers for trials, and globally we are probably looking at tens of thousands participating in trials.
It shouldn't be surprising. They get thousands of volunteers for other vaccine trials that are much less urgent. Imagine how much easier it is for a current pandemic.
 
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  • #3,677
morrobay said:
Yes increased infectivity but are there any data/studies showing whether the D614G mutation is more or less lethal?

The infectivity refers to cell culture data, and may not apply to transmissibility (though it is consistent with the variant becoming more common). One of the papers looking at the variants was not able to find any difference in severity between them: https://www.cell.com/cell/pdf/S0092-8674(20)30820-5.pdf
 
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  • #3,678
atyy said:
For the flu vaccine, there seems to be debate about making it mandatory for various groups of people.

No debate for me. I do not know if being on the cocktail of drugs I am on it is a requirement I have it, but when I see my doctor it's where do you want it.

Thanks
Bill
 
  • #3,680
I found some interesting stuff on the Internet (which I have cited below) regarding dogs trained to detect covid-19.
I have not been able to find any peer review articles about the details of the training. I hope someone can help me find some.

I also have an mp4 file which I think may be from facebook. I have not included it in this post because I am not sure about the relevant PFs' rules.
 
  • #3,681
Has the definition of what constitutes a new case recently changed? Are they including 'probable' cases as new cases now? Are they also including people who test positive for antibodies but never were tested for the virus as 'new' cases too?
 
  • #3,682
bob012345 said:
Has the definition of what constitutes a new case recently changed? Are they including 'probable' cases as new cases now? Are they also including people who test positive for antibodies but never were tested for the virus as 'new' cases too?
That's hard to say, and it probably depends on who is doing the reporting. I believe 'probable' cases are treated separately, but it's not clear how uniform and consistent the reporting is across 50 states and the 3000+ counties.

See different ways of reporting
Alabama - https://alpublichealth.maps.arcgis..../index.html#/6d2771faa9da4a2786a509d82c8cf0f7
Arizona - https://www.azdhs.gov/preparedness/...se-epidemiology/covid-19/dashboards/index.php
California - https://www.cdph.ca.gov/Programs/CID/DCDC/Pages/Immunization/ncov2019.aspx#
Florida - https://experience.arcgis.com/experience/96dd742462124fa0b38ddedb9b25e429
New York - https://covid19tracker.health.ny.gov/views/NYS-COVID19-Tracker/NYSDOHCOVID-19Tracker-Map
Texas - https://txdshs.maps.arcgis.com/apps/opsdashboard/index.html#/0d8bdf9be927459d9cb11b9eaef6101f
Washington - https://www.doh.wa.gov/Emergencies/NovelCoronavirusOutbreak2020COVID19/DataDashboard

Compare to https://ncov2019.live/data/unitedstates and https://covidtracking.com/data
ncov2019.live has greater numbers than reported by the states, so I believe they may count some 'probable' positive cases and deaths in their numbers. However, the discrepancies are not clear to me.

Meanwhile, CNN reports that Governor Kevin Stitt of Oklahoma has tested positive for COVID-19
https://www.cnn.com/2020/07/15/politics/kevin-stitt-oklahoma-governor-coronavirus/index.html

The health department reports that it is not clear how he was exposed. "Dr. Lance Frye, the commissioner of the Oklahoma State Department of Health, said they don't know exactly when Stitt was infected, but that it would've been within the last couple of weeks."

Update: NY Times reported on how states report deaths - probable and confirmed
https://www.nytimes.com/interactive/2020/06/19/us/us-coronavirus-covid-death-toll.html
 
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  • #3,683
Incomplete classification, but still an interesting observation.

538DD61D-EF6C-4FF6-96A2-84445D9080BD.jpeg


https://www.google.com/amp/s/hbr.or...pandemic-reshape-notions-of-female-leadership
 
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  • #3,684
I like New Zealand's response. Real competent leadership.
 
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  • #3,685
Jarvis323 said:
Incomplete classification, but still an interesting observation. View attachment 266419

One of the things a lot of journalists have struggled with re the COVID-19 pandemic is the concept that different countries have different populations and the total numbers are not comparable. Only numbers adjusted for population are comparable. And also that countries are geographically very different.

If, for example, you compare Iceland with the less populated and more remote US states, there's a general correlation:

PerMillion
PopCasesDeathsCasesDeaths
Iceland
340,000​
1,900​
10​
5,600​
29​
Wyoming
580,000​
2,000​
22​
3,400​
38​
Alaska
730,000​
1,600​
17​
2,200​
23​
Hawaii
1,400,000​
1,300​
22​
900​
16​

Therefore, if we compare Iceland with comparable US states, then the picture is very different.
 
  • #3,686
PeroK said:
One of the things a lot of journalists have struggled with re the COVID-19 pandemic is the concept that different countries have different populations and the total numbers are not comparable. Only numbers adjusted for population are comparable. And also that countries are geographically very different.

If, for example, you compare Iceland with the less populated and more remote US states, there's a general correlation:

PerMillion
PopCasesDeathsCasesDeaths
Iceland
340,000​
1,900​
10​
5,600​
29​
Wyoming
580,000​
2,000​
22​
3,400​
38​
Alaska
730,000​
1,600​
17​
2,200​
23​
Hawaii
1,400,000​
1,300​
22​
900​
16​

Therefore, if we compare Iceland with comparable US states, then the picture is very different.
That's true; but it's worth considering that Iceland has done more than twice as much testing per capita as the US.
 
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  • #3,687
Jarvis323 said:
That's true; it's still not clear though because we can't fairly compare the numbers directly. Iceland has done more than twice as much testing per capita than the US. Who knows how much testing Alaska has done, or how accurate the death counts are. And then there is chance. With deaths in the 10-20 range, chance can be a pretty big factor. And what strain showed up, when is an important factor.
Comparing an island country of 300,000 with a country of 300,000,000 is fundamentally problematic. You want to say that Iceland vs the USA is a logical and valid comparison; but Iceland vs Alaska is not?
 
  • #3,688
PeroK said:
Comparing an island country of 300,000 with a country of 300,000,000 is fundamentally problematic. You want to say that Iceland vs the USA is a logical and valid comparison; but Iceland vs Alaska is not?
I'm just pointing out that even your adjustment doesn't cut it. Just an estimate, after looking here and some other places, (https://www.politico.com/interactives/2020/coronavirus-testing-by-state-chart-of-new-cases/), I would say that Alaska, Hawaii, and Wyoming have likely undercounted compared with Iceland by about a factor of 4 or more.

But the numbers are low enough to just observe Iceland did good. You can compare one state to Iceland, but the leader of the US is in charge of the whole country. So that comparison is not a comparison of national leadership.

You can't be asking for too much more performance from Iceland, but there is a lot more to ask of the US. Of course there are differences due to population density and so forth. So, maybe you can say the US leadership has a different problem (maybe a harder one), but you can't say they did a good job.

So one leader had a better outcome than the other, but one may have had an advantage. The next thing to do is compare actions. I think the articles in the topic are looking at that as well, and it's those comparisons which really highlight leadership quality differences in my opinion.
 
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  • #3,689
Jarvis323 said:
I'm just pointing out that even your adjustment doesn't cut it.

I wasn't trying to make a definitive case. I simply highlighted the absurdity of the data analysis I was presented with.
 
  • #3,690
PeroK said:
I wasn't trying to make a definitive case. I simply highlighted the absurdity of the data analysis I was presented with.
What are you talking about, the testing rate I mentioned? It seams Iceland has tested a much larger percentage of it's population, which you didn't account for. That's all the data analysis I did.
 
  • #3,691
Confirmed cases in the US exceeded 1% of its population.

Excluding micronations/territories with a small population: Qatar has 3.5%, Bahrain about 2%, Chile and Kuwait about 1.5%, Oman, Armenia, Panama, Peru and the US a bit more than 1%. Brazil has a bit less than 1% at the moment.
 
  • #3,692
mfb said:
Confirmed cases in the US exceeded 1% of its population.

Excluding micronations/territories with a small population: Qatar has 3.5%, Bahrain about 2%, Chile and Kuwait about 1.5%, Oman, Armenia, Panama, Peru and the US a bit more than 1%. Brazil has a bit less than 1% at the moment.

One noticeable thing is that the Middle East countries with a large number of cases - Qatar, Bahrain, Kuwait, Oman and Saudi Arabia - have a very low death rate. Not just a low CFR, but a low death rate per population generally. For example:

Saudi Arabia and Italy both have about 243,000 cases now: Italy has had 35,000 deaths, but SA only 2,370.

Canada and Qatar have 109,000 and 105,000 cases respectively, but 8,800 against 150 deaths.

Belgium and Oman have about 63,000 cases each, but 9,800 against 290 deaths.

(As an aside, the global death rate generally is about 60 people per 100,000 per month. If you picked 100,000 of the world's population at random, then about 60 would die in the next month. In other words, 150 deaths from 100,000 people is about the expected death rate given the time COVID-19 has been around.)
 
  • #3,693
With 13% world pop obese. (U.S. 40%) 9% diabetes. 27% hypertension.Thats about 1/2 co morbidities for world population.
 
  • #3,694
morrobay said:
With 13% world pop obese. (U.S. 40%) 9% diabetes. 27% hypertension.Thats about 1/2 co morbidities for world population.

It's worse than 9% for diabeties in the sense that even pre-diabeties is a significant risk factor. It is estimated 1 in 3 people have diabeties or pre-diabeties. I think there is well over 50% of the population with at least one co-morbidity. Over 65 I think a person without a co-morbidity is very much the exception rather than the rule. I do not know if the reason the elderly have a higher death rate is their age or co-morbidities.

Thanks
Bill
 
  • #3,695
The Oxford team developing a adenoviral-based vaccine is planning to test their vaccine by intentionally exposing vaccinated volunteers to the virus:

The team behind the Oxford Covid-19 vaccine hope to begin tests on volunteers who will be intentionally exposed to the virus in a “challenge trial”, a move seen as controversial since there is no proven cure for the illness.

Although challenge trials, in which healthy volunteers are given a pathogen, are routine in vaccine development, taking the approach for Covid-19, where there is no failsafe treatment if a volunteer becomes severely ill, has been questioned.

In human challenge trials volunteers are intentionally exposed in a controlled laboratory setting, meaning the trial can be completed in weeks and requires far fewer people.
https://www.theguardian.com/science...lunteers-lab-controlled-human-challenge-trial

While these challenge trials would quickly be able to give an idea of the efficacy of the vaccine (how well does it protect against infection by the coronavirus), the trial would not provide sufficient data on safety. The safety data would have to come from ongoing phase III trials from the group (which will also provide more data on efficacy in real world situations). According to the Guardian article above, the phase III trials have "recruited 10,000 trial participants in the UK, about 5,000 in Brazil and 2,000 in South Africa, with a second trial in the US aiming to recruit as many as 30,000 participants."
 
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  • #3,696
Ygggdrasil said:
The Oxford team developing a adenoviral-based vaccine is planning to test their vaccine by intentionally exposing vaccinated volunteers to the virus:

I expected that. The Oxford group is very gung ho - I have even heard some refer to them as 'crazy'. It certainly will speed up getting the vaccine out there, but even with volunteers I have concerns about its 'morality'.

This is partly related to the view of some working on vaccines that the Oxford vaccine approach has some inherent problems:
https://www.hospitalhealth.com.au/c...id-19-says-professor-1538816326#axzz6STOe3pbD

At a minimum I would want any volunteer to be aware of the above issues.

I like the suggestion of Professor Petrovsky that, once proven safe, as part of phase 2 trials, using the vaccine to attempt to break up second wave outbreaks. He is preparing plans to do that with his vaccine if the Victoria outbreak gets out of hand and threatens a second wave across all of Australia.

Thanks
Bill
 
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  • #3,697
Several US states register over 0.1% of their population as new cases every week. With 30,000 participants that's over 30 new cases per week if the vaccine does nothing, even if you don't add dedicated tests. Give half of them a placebo, skip the first two weeks, three weeks later you expect 50-100 new cases in the control group and can compare this with the group that got a vaccine. This number might go down in the future if the states get the outbreak under control, of course.

Testing everyone in both groups twice in that time span will increase the statistics a lot (and will give another data point on how many cases the US is missing).
 
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  • #3,698
There is some seemingly good news about immunity.

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
Memory T cells induced by previous pathogens can shape the susceptibility to, and clinical severity of, subsequent infections1. Little is known about the presence of pre-existing memory T cells in humans with the potential to recognize SARS-CoV-2. Here, we first studied T cell responses to structural (nucleocapsid protein, NP) and non-structural (NSP-7 and NSP13 of ORF1) regions of SARS-CoV-2 in COVID-19 convalescents (n=36). In all of them we demonstrated the presence of CD4 and CD8 T cells recognizing multiple regions of the NP protein. We then showed that SARS-recovered patients (n=23) still possesses long-lasting memory T cells reactive to SARS-NP 17 years after the 2003 outbreak, which displayed robust cross-reactivity to SARS-CoV-2 NP.

https://www.nature.com/articles/s41586-020-2550-z

T-cell immunity tests could be more reliable than antibody tests in measuring the spread of coronavirus in the community, according to a new study.

Scientists have found that some patients who had experienced mild symptoms of Covid-19 did not appear to have developed antibodies. However they did show “strong, specific T-cell immunity”, according to the authors of a report in Science Immunology.

“If, as appears the case, measuring T-cell immunity is a more enduring and reliable marker of adaptive immunity in Covid-19 than antibody, it will be valuable to achieve roll-out for health services of commercial T-cell testing kits,” said Rosemary Boyton and Daniel Altmann, professors of immunology at Imperial College London.

https://www.independent.co.uk/news/...-test-t-cell-antibody-community-a9625811.html

Since it has been observed that anti-bodies to sars-ncov-2 can fade quickly, this seems like good news for long term immunity; we may not need anti-bodies. I'm not sure though what it really means, and how it affects vaccines, but it is being suggested it is an important factor.

Moderna’s Phase 1 study also indicated that its vaccine candidate can offer a double defense against the virus. The Telegraph explains that it may be essential for vaccines to provide this type of advanced protection to increase COVID-19 immunity. Not all vaccine candidates will also produce T cells, the report notes. Apparently, at least one major vaccine candidate in China does not lead to T cell production, although The Telegraph doesn’t name the drug.

https://bgr.com/2020/07/15/coronavirus-cure-moderna-vaccine-phase-3-news/
 
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Likes atyy
  • #3,699
Stretches of South Texas, especially the Rio Grande Valley and the Coastal Bend, have seen Coronavirus infections spread so quickly in recent weeks as to push local hospitals to their limit. The four-county region that includes Harlingen has just 21 ICU beds still available for a population of about 1.4 million people, according to the latest state data, and ambulance operators have described wait times of up to 10 hours to deliver patients to packed emergency rooms.
https://www.texastribune.org/2020/07/18/texas-coronavirus-hot-spots/
Last Friday, Nueces County Medical Examiner Adel Shaker was shocked to learn that a baby boy, less than 6 months old, had tested positive for COVID-19 and died shortly after.
No mention of a pre-existing condition or co-morbidity.
Two weeks ago, there were just seven positive COVID-19 patients in the Amarillo hospital; by this week, that had more than tripled to 24. Earlier this week, a patient in their 30s died; now, the family of a patient in their 40s is considering withdrawing care.

States of Texas and Florida both reported record high deaths from COVID-19 on Thursday, as states in the south and west of the U.S. continue to bear the brunt of the pandemic.
https://www.newsweek.com/record-coronavirus-deaths-reported-texas-florida-1518617

Florida reported 156 new Coronavirus deaths and nearly 14,000 new cases on July 16, with fatalities from the disease in the state having increased significantly since the end of June and beginning of July, according to the COVID Tracking Project.

On July 1, the seven-day moving average of deaths in the state was 38, whereas on July 16 the figure was 95, according to the Johns Hopkins Coronavirus Resource Center.
 
  • #3,700
The link between blood type and Covid-19 is BS

Native Americans are nearly 100% type O, yet Covid-19 rages across Latin America and threatens to wipe out indigenous groups in the Amazon.

and this study was just published“We showed through a multi-institutional study that there is no reason to believe being a certain ABO blood type will lead to increased disease severity, which we defined as requiring intubation or leading to death,” said senior study author Anahita Dua, HMS assistant professor of surgery at Mass General.

“This evidence should help put to rest previous reports of a possible association between blood type A and a higher risk for COVID-19 infection and mortality,” Dua said.

https://hms.harvard.edu/news/covid-blood-type
 

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