COVID COVID-19 Coronavirus Containment Efforts

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Containment efforts for the COVID-19 Coronavirus are facing significant challenges, with experts suggesting that it may no longer be feasible to prevent its global spread. The virus has a mortality rate of approximately 2-3%, which could lead to a substantial increase in deaths if it becomes as widespread as the flu. Current data indicates around 6,000 cases, with low mortality rates in areas with good healthcare. Vaccine development is underway, but it is unlikely to be ready in time for the current outbreak, highlighting the urgency of the situation. As the outbreak evolves, the healthcare system may face considerable strain, underscoring the need for continued monitoring and response efforts.
  • #2,161
Astronuc said:
I thought some nations would give those who recovered a certificate that they had been treated and recovered. I don't know if that's the case in the US. I suppose one could request a note from a doctor, or health department.
There won't be very many of them. If we believe the figures and stop this phase at around 70,000 recovered in the UK, say, that's only 0.1% of the population. That leaves 999 people out of every 1000 still in lockdown - or, not in the clear.
 
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  • #2,162
Various news sources are reporting UK Prime Minister Boris Johnson was moved to the intensive care unit at St. Thomas's Hospital, according to a Downing Street. Two sources indicate the move to ICU came after his condition (COVID-19) worsened.

BBC - https://www.bbc.com/news/uk-52192604
 
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  • #2,163
As one of many famous people getting Covid-19, the UK prime minister Boris Johnson has recently been taken into intensive care. He is 55 years old.

Source: Coronavirus: Boris Johnson taken into intensive care (The Guardian, 6 april 2020)

EDIT: I saw @Astronuc was faster than me.
 
  • #2,164
Aiyoh ...
 
  • #2,165
PeroK said:
There won't be very many of them. If we believe the figures and stop this phase at around 70,000 recovered in the UK, say, that's only 0.1% of the population. That leaves 999 people out of every 1000 still in lockdown - or, not in the clear.
It includes a significant share of the healthcare workers - probably even more than the confirmed cases among them.

Folding@Home has COVID-19 packages. If you have a computer that isn't 100% busy with other tasks you can contribute some CPU cycles to searches for vaccines or cures: Folding@Home
You can't select COVID-19 in particular, but if you keep it set to "any disease" the chance to get one of these is probably quite high. My computer is working on one right now.
 
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  • #2,166
peanut said:
Unfortunately, in the third world countries, where everyone is crammed into a tight space, some people seriously think the kids won't bring the virus home, or if they get it from their home, bring it to school? And who brings a lot of kids to school? Adults! Plus the teachers. And you know what? Grandma and grandpa live with these kids! If they contract the virus it may kill them. And I think the reason why testing of kids isn't done much: (two words) nasopharyngeal swab. Try sticking that baby down your 7-year old's nose. No. Schools should stay closed. .
Think of those crammed in slums with 60,000+ per square mile.
 
  • #2,167
Boris Johnson moved to ICU. Sorry, I have a phone and don't know how to cut and paste for sourcing.
 
  • #2,168
A few points. One is that Nate Silver (former bookie and now runs Five Thirty Eight) has a pretty good write up Corona Case Counts are Meaningless. His point is that number is sampled and calculated differently in different places, and is not a very good indicator of what is going on.

Second, @Astronuc seems to have taken issue with my claims that the Washington flu numbers are underestimated (although they are probably underestimated by the same factor year to year). So here's my comparison between flu and Covid.

1. Europe:

Thanks to @Stephen Tashi , we have total death statistics from Europe from all causes. Europe has been both harder hit and is in a later stage of the epidemiology than the US.

1586220069280.png

That uptick in 65+ and Total at the very end is Covid. The downtick in the other age groups is hypothesized by @russ_watters to be a side effect of lockdowns. You can see the spikes (which look like lumps) in the last three winters. The CDC US death estimates for flu for those years was, starting with 2018-9 and working backward, 34K, 61K (in two phases) and 28K, these are all fairly high years. Low years are more like 20K, sometimes as low as 12K.

Comparing the relative heights of the Covid spike with the Flu "spikes" tells you something about the relative number of fatalities without needing to correctly account for any individual death.

2. Greater New York City:

I am going to start with the Diamond Princess data. Since everyone was tested, we have a fairly good dataset. Furthermore, the population density is about the same as Manhattan: 68000 per square mile. It's also the density of greater NYC, defined as the five boroughs and nearby cities in New Jersey, but not counting Long Island, Connecticut etc.

On the Diamond Princess, they had everyone interacting in close quarters until the first symptoms showed (about two weeks), and then they locked everything down. Not too different than NY. So we have a pretty good, but not perfect, proxy.

18% of the passengers and crew tested positive, and the fatality rate is 1.8%. However, cruise demographics skews elderly. The median age of cruise passengers is 65. The US as a whole has 14% of its population 65+. Since the disease affects primarily the elderly, there should be a correction of 14/50 to the 1.8%, making it 0.5%. That doesn't count the crew (none of whom died), so 0.7% is probably closer.

If you say 15M people in the NYC area, 2.7M of them will be infected if you treat it as a giant cruise ship. About 20K will die. Time will tell how accurate this model is. If you just take the NYC numbers and place them over the Hubei graph, extrapolate, and correct for the inner suburbs, you get 22K.

How many died of the flu in the same window? Assuming 34,000 deaths in the country, like last year, that would correspond to about 1600. A bad year would be twice that, and a good year half that. How many die in a year from all causes? About 130,000.

How does this extrapolate to the rest of the country? No idea. The 18% number will come down, but I have no idea how much. I'd need at least one more data point.
 
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  • #2,169
kolleamm said:
I know the quarantine is helping slow the spread of the virus, but my question is why are the cases still rising? Where are all these people getting sick from?
There are still groceries, pharmacies and supply chain workers (trucking, warehouse, gas stations, ...).
 
  • #2,170
An interesting active research topic:

In conclusion, although there is no conclusion regarding the association of COVID-19 with RAS inhibitors, RAS inhibitors can affect the expression of ACE2 mRNA and the activity of ACE2 in tissues; theoretically, it is possible that ACE2 could promote the proliferation of COVID-19 and enhance its capability for infection. Therefore, large-scale clinical studies are urgently needed to explore COVID-19 susceptibility and corresponding treatment strategies in patients with hypertension treated with RAS inhibitors.

https://www.nature.com/articles/s41440-020-0433-1
 
  • #2,171
@Vanadium 50: Nice analysis.

Two comments:

Out of the 712 infections, 145 were among the crew and 567 among the passengers. If you limit the extrapolation of deaths to the older passengers you should do this with infections as well, increasing the deaths by ~20%.

The 15 million people will normally have 45,000 hospital beds, out of these 15,000 free, and 5,000 total ICU beds if the US average applies to NYC. If 20,000 die then about 60,000 will need an ICU bed, 30,000 of them will need a ventilator, and 100,000 to 300,000 will get pneumonia, taking ratios from China. If these are not available then the case fatality rate will go up. The Diamond Princess cases all had access to hospitals.
If the areas around NYC see weaker outbreaks they can take some patients from NYC. If they see similar outbreaks this won't work.
 
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  • #2,172
mfb said:
As far as I know other countries consider something similar.

As soon as the serology test is available here in Aus, that is exactly what they are looking at. I have even heard talk they might be 'encouraged' into front line work with hospitals, the elderly etc. I hope that encouragement is just that - the last thing we want here with all the restrictions we currently have is some kind of 'forced' conscription.

Thanks
Bill
 
  • #2,173
Rive said:
Unfortunately, no. Usually flu comes with much lower death rate and in this vaccianation actually makes no difference: that effects only the R0 value.
Novel flu can do something similar, at least we know a case when it did.

:H:H:H:H:H - Knucklehead - of course you are right - the vaccine mainly just affects R0. In may have a bit of an effect on death rate in that it is reported if you are vaccinated your case is generally milder if you do manage to get it. Well back to the drawing board. The spanish flu had a death rate of 2% - higher than the current flu strains floating around and it seems higher than Coronovirus. Excluding the Ruby Princess debacle our death rate has increased from .4% to .6% which is slightly concerning and the government wants to do more local testing to see if it's just the quarantining in hotels of those arriving in Australia lowering the denominator. But it looks like its death rate is not as bad as the Spanish flu. Interestingly the swine flu had a phenomenally low death rate - estimated 0.001% to 0.007%

Thanks
Bill
 
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  • #2,174
While writing my last post something occurred to me. The timeline it took to get the Swine Flu vaccine was research started April 2009 and a vaccine became available December 2009. Why is the Coronovirus vaccine taking longer? We had many vaccines in a few weeks during January - the UQ vaccine took just 3 weeks. So it would seem testing is taking longer - why is that?

Thanks
Bill
 
  • #2,175
bhobba said:
Why is the Coronovirus vaccine taking longer?
For flu vaccines, the already proven (safe, working) technology remains the same, only the strain(s) changes so a shortened, rapid trial is acceptable. But for the Covid19 an entirely new technology is needed: the approval process is a lot more complicated and longer.

bhobba said:
...The spanish flu had a death rate of 2%...
Well, actually we don't know that, not exactly. Flu also can be asymptomatic, and I don't know if/how that was accounted in that number.
And without the asymptomatic cases, we are in the same range with the Covid19 too.
 
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  • #2,176
An at-home fingerprick blood test may help detect your exposure to coronavirus
If approved, the blood test could show if your immune system has developed Coronavirus antibodies. But a positive result isn't a license to return to work.

https://www.nbcnews.com/health/heal...elp-detect-your-exposure-coronavirus-n1176086

I am greatly hoping this is fast-tracked. I would want to know for me and my family if we've been exposed and may have immunity or not.

A Los Angeles digital healthcare company called Scanwell Health is seeking U.S. government clearance for a kit that let's users submit a scanned image of a blood test to doctors via their phones. Within a few hours, according to the company, the user will learn whether the blood contains antibodies for coronavirus.

"The entire testing process happens at home," says Scanwell Chief Medical Officer Jack Jeng, "No specimen has to be shipped back."

A positive test result means a patient has been exposed to COVID-19 at some point in the past and has developed antibodies to fight it.

"The Scanwell rapid serology test is looking for antibodies in the blood. A positive test result means that you were exposed to the virus previously because it takes time for the antibodies to develop," said Jeng.

David Kroll, a professor of pharmacology at the University of Colorado who has worked on antibody testing, explained that the antibodies mean "your immune system [has] remembered the virus to the point that it makes these antibodies that could inactivate any future viral infections."

What the test can't do is tell you whether you're currently sick with coronavirus, whether you're contagious, whether you're fully immune — and whether you're safe to go back out in public.

Because the test can’t be used as a diagnostic test, it would need to be combined with other information to determine if a person is sick with COVID-19.

"However, when combined with symptoms consistent with COVID-19 like a fever, cough, and sore throat, a positive test is pretty much diagnostic for the illness," said Jeng, "That is how these rapid serology tests are being used in China."

Does anyone know how to interpet the bolded part? Would anti-bodies not tell us we're fully immune already?
 
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  • #2,177
kyphysics said:
An at-home fingerprick blood test may help detect your exposure to coronavirus
If approved, the blood test could show if your immune system has developed Coronavirus antibodies. But a positive result isn't a license to return to work.

https://www.nbcnews.com/health/heal...elp-detect-your-exposure-coronavirus-n1176086

I am greatly hoping this is fast-tracked. I would want to know for me and my family if we've been exposed and may have immunity or not.

A Los Angeles digital healthcare company called Scanwell Health is seeking U.S. government clearance for a kit that let's users submit a scanned image of a blood test to doctors via their phones. Within a few hours, according to the company, the user will learn whether the blood contains antibodies for coronavirus.
Does anyone know how to interpet the bolded part? Would anti-bodies not tell us we're fully immune already?

You usually need a certain level of antibodies to be protected. So if you have antibodies, but only a low level, you may not be protected.

The test may not be a quantitative test, so it may not be able to say whether you have a low or a high level of antibodies. Also, we probably don't know at this stage what "minimum" level is needed to be protected.

You can see these considerations in more common vaccines like Hepatitis B and tetanus vaccination. The antibody level may decrease over time, and one may need a booster vaccination.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512724/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826453/
 
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  • #2,178
kyphysics said:
Does anyone know how to interpet the bolded part? Would anti-bodies not tell us we're fully immune already?
That is a disclaimer. Scientifically, the test determines the presence of antibodies, which would indicate exposure and infection, but it does not determine whether you're currently sick with Coronavirus (one would need to measure temperature (fever) and other symptoms (X-ray for lung opacity, measure oxygen level in blood)), whether you're contagious (test doesn't measure viriods or virus being exhaled, for example), whether you're fully immune (more complicated testing required).
 
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  • #2,179
Astronuc said:
That is a disclaimer. Scientifically, the test determines the presence of antibodies, which would indicate exposure and infection, but it does not determine whether you're currently sick with Coronavirus (one would need to measure temperature (fever) and other symptoms (X-ray for lung opacity, measure oxygen level in blood)), whether you're contagious (test doesn't measure viriods or virus being exhaled, for example), whether you're fully immune (more complicated testing required).
Any idea if tests for full immunity can even be theoretically created right now?

Or, is it too early?
 
  • #2,180
atyy said:
You usually need a certain level of antibodies to be protected. So if you have antibodies, but only a low level, you may not be protected.

The test may not be a quantitative test, so it may not be able to say whether you have a low or a high level of antibodies. Also, we probably don't know at this stage what "minimum" level is needed to be protected.

You can see these considerations in more common vaccines like Hepatitis B and tetanus vaccination. The antibody level may decrease over time, and one may need a booster vaccination.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512724/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826453/
Thanks for the helpful reply!
 
  • #2,181
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  • #2,182
France not reached peak yet amid nearly 9,000 dead; outdoor physical exercises banned from 10AM to 7PM in Paris
 
  • #2,184
Stupid question: does certifying recovered patients to return to work create an incentive for others to try to expose themselves to the disease?

If you really need to be back in the workforce to support yourself/your family, but the only way you can get back to work is to have recovered from covid-19, then you may end up concluding that risking a 1 in 5 chance of serious illness is preferable to almost certainly being out of work for an indefinite but prolonged period of time.
 
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  • #2,185
TeethWhitener said:
Stupid question:...
I do know about some who actually considered this.
I do not think that it is a good idea.
I think this kind of thing should be considered crime.
 
  • #2,186
TeethWhitener said:
Stupid question
Government policies might reduce that incentive, but it's an interesting question.
mfb said:
You can bring back economic growth. You can't bring back dead people.
Today I learned that the president of Ghana https://www.thelondoneconomic.com/politics/president-of-ghana-provides-much-needed-perspective-in-these-troubling-times/29/03/ almost literally a week ago.

----

https://annals.org/aim/fullarticle/2764367/effectiveness-surgical-cotton-masks-blocking-sars-cov-2-controlled-comparison
In conclusion, both surgical and cotton masks seem to be ineffective in preventing the dissemination of SARS–CoV-2 from the coughs of patients with COVID-19 to the environment and external mask surface.

Italy's new cases are the lowest number in three weeks:
Italy.png
 
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  • #2,187
I was just listening to New York governor Andrew Cuomo give his daily update. He mentioned a coordinated effort with the state of New Jersey. Cuomo mentioned an increase in deaths, which is a lagging indicator compared to hospitalizations, for which the three-day average has decreases. Cuomo mentioned last week that the longer someone is on a ventilator, the less likely they will come off the ventilator, which is still the case, and he mentioned that some patients had been on ventilator for 20 to 30 days.

Cuomo talked about availability of beds, the capacity of which has increased. On the other hand, a local county has one ICU bed available and the will be filled soon before the end of the week. Discharges from hospital have increased, so some folks are recovering.

NY state has reported 138836 positive cases and 5489 deaths so far.

Before Cuomo spoke, a reporter for a regional news service (covering NY, CT, MA and VT) mentioned that there was a cluster of deaths and positive COVID-19 at some senior living (retirement) centers. In one case, people who were tested negative last week have since developed symptoms of COVID-19. It was not clear if they have been retested.
 
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  • #2,188
peanut said:
Yes. Though there is very LITTLE data on any kind of ASYMPTOMATIC transmission precisely because these people are hard to identify. PRESYMPTOMATIC transmission does seem to occur and may be responsible for probably up to 10% of transmission. The MAJORITY (about 90%) of transmission STILL seems to occur from symptomatic individuals.
Caroline Chen, April 2, 6 a.m. EDT
https://www.propublica.org/article/...ic-carriers-if-were-going-to-beat-coronavirus
What We Need to Understand About Asymptomatic Carriers . . .
With articles about “silent spreaders” and “stealth transmission” flying across the internet, friends were starting to text me: Was it still OK to go for a walk with a friend, even 6 feet apart? Or should all interaction be avoided? Should we start wearing masks to the grocery store? At the same time, my colleagues were scrutinizing guidelines at various workplaces and agencies we cover: The New York City Fire Department told workers on March 19 they were to come to work, so long as they had no symptoms, even if they had had “close contact with someone who is a known positive COVID-19 patient,” according to a document obtained by ProPublica. Was that policy wise?
. . . .
What does asymptomatic really mean?
Let’s start with the basics. Dr. Maria Van Kerkhove, head of the emerging diseases and zoonoses unit at the World Health Organization, told me that the WHO so far has found few truly asymptomatic cases, in which a patient tests positive and has zero symptoms for the entire course of the disease. However, there are many cases where people are “pre-symptomatic,” where they have no symptoms at the time when they test positive but go on to develop symptoms later.

“Most of the people who were thought to be asymptomatic aren’t truly asymptomatic,” said Van Kerkhove. “When we went back and interviewed them, most of them said, actually I didn’t feel well but I didn’t think it was an important thing to mention. I had a low-grade temperature, or aches, but I didn’t think that counted.”
The article mentions a WHO study in China and a CDC study of a nursing home in Washington state (probably the Life Care Center in Kirkland).
 
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  • #2,189
does the microwave kill the virus?
 
  • #2,190
kolleamm said:
does the microwave kill the virus?
Why would it matter? If you got the virus, would you plan on dousing your body with microwaves?

Shooting microwaves at surfaces might not be quite as dangerous as that, but would likely be dangerous. Cataracts, anyone?
 

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