Cramer's Rule can be applied in the frequency domain since it operates with complex numbers, which form a field similar to real numbers. While it can simplify solving two simultaneous equations by hand, it may not be the most efficient method. For computational purposes, using matrix math or functions like rref() in software such as MATLAB is recommended, especially if the calculator supports complex numbers. Ultimately, the choice of method depends on the context and tools available. Cramer's Rule is valid but may not always be the optimal approach for solving equations in the frequency domain.