Erasing memories via memory reconsolidation

  1. Pythagorean

    Pythagorean 4,622
    Gold Member

    A review of memory reconsolidation[1], the recent experiment in which memory traces were attenuated[2] and a caveat that recovery of the fear memory is typical in patients [3].


    [1]
    http://www.nature.com/nrn/journal/v8/n4/abs/nrn2090.html




    [2]
    http://www.sciencemag.org/content/337/6101/1550.abstract



    [3]
    http://www.annualreviews.org/doi/abs/10.1146/annurev-clinpsy-050212-185542
     
  2. jcsd
  3. atyy

    atyy 10,624
    Science Advisor

    Let's say I'm a Sumerian kid who's afraid of school because I was bad at spelling and the teacher caned me. Does the erasure erase only the fear, or also that the memory that the teacher caned me?
     
  4. Pythagorean

    Pythagorean 4,622
    Gold Member

    I doubt the explicit autobiographical memory is erased. Only the implicit memory is erased and it can apparently be reconstructed (probably through the autobiographical memory).
     
  5. Ygggdrasil

    Ygggdrasil 1,652
    Science Advisor

    There was also a recent paper from the Tonegawa lab where they used optogenetic techniques to implant a "false memory" into rats:

    Ramirez et al. 2013 Creating a False Memory in the Hippocampus. Science: 341, 387. doi:10.1126/science.1239073
     
  6. atyy

    atyy 10,624
    Science Advisor

    You're thinking this because of the third reference in the OP in which the fear returns after it has been extinguished?
     
  7. Pythagorean

    Pythagorean 4,622
    Gold Member

    Yes. The review (the third reference) goes into both extinguishing and reconsolidation (and a mixture of the two). It indirectly references the second reference in the OP. They don't explicitly say that the implicit memory returns because of declarative memory, that's speculation on my part.

    Interestingly, another reference in the review did actually find an affect on declarative memory:
    http://www.sciencedirect.com/science/article/pii/S030105111200021X
     
  8. Pythagorean

    Pythagorean 4,622
    Gold Member

    Here's the psychology equivalent from all the way back in '95:
    http://www.grangebehaviouralsciences.com/uploads/1/0/1/9/10197659/loftusmem1.pdf

    If I remember correctly, they basically ask people to recall a memory and ask them questions about it, but some of the questions are loaded (i.e. assume a false pretense). Later, when asked about it, ~30% of people believe the false pretense to be a true part of their memory.
     
  9. atyy

    atyy 10,624
    Science Advisor

    By declarative memory are you referring to "At a cognitive level, propranolol directly impaired extinction learning." ? (Sorry, I should read this myself, but am too lazy, so I'll just ask you:)
     
  10. Pythagorean

    Pythagorean 4,622
    Gold Member

    yeah, declarative/explicit/consciously available memories like autobiographical/episodic as opposed to implicit/unconscious memories like procedural.
     
Know someone interested in this topic? Share a link to this question via email, Google+, Twitter, or Facebook

Have something to add?

0
Draft saved Draft deleted
Similar discussions for: Erasing memories via memory reconsolidation
Loading...