Grades on transcripts generally hold little weight when applying for postdoc positions, with the focus primarily on research history, contacts, research statements, and recommendation letters. Most postdoc applications do not require transcripts, particularly in North America, though some faculty positions may request them later in the career. In Europe, the situation may differ, especially in high-energy physics, where maintaining a B average is crucial, and failing grades can significantly impact a student's standing. While an F is rare and would raise concerns among faculty, the overall ability to conduct research and form collaborations is deemed more critical. Personal circumstances affecting grades may be considered, but consistent poor performance could indicate a mismatch with the field. Ultimately, candidates are evaluated on their potential to complete projects and their fit within the candidate pool.