Fluids (Through an IV) Question

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In an emergency department discussion, a trauma tech questioned the fastest method for administering IV fluids to a critically ill patient. An experiment revealed that using a single IV line and changing bags after one runs dry was faster than connecting two bags to one line. The reasoning suggests that connecting multiple bags increases turbulence and pressure drop at the junction, which ultimately slows fluid flow. The pressure driving the flow is determined solely by the height of the fluid, not the quantity, meaning two bags at the same height do not increase pressure. This highlights the importance of minimizing turbulence and maintaining optimal flow conditions in IV administration.
  • #31
Andy Resnick said:
Thanks- apology accepted. So let's get on with it:



That's not relevant, unless (1) the needle is microscopic in diameter, so that the continuum approximation breaks down, (2) the needle is so short that Poiseuille flow does not develop, or (3) the Reynolds number becomes large enough to indicate turbulent flow. None of these conditions are likely to be met in practice.

The narrowest part of the line will lead to the biggest pressure loss. If you look at the expression for pressure drop here http://en.m.wikipedia.org/wiki/Hagen–Poiseuille_equation it scales like r^-4 so width often has a very dominant effect. For the reasons you mention, I suppose (guessing here) this throttling position will be upstream from the needle to allow cavitated bubbles to dissolve.

I don't understand what you mean by friction- the no-slip boundary condition means there is no frictional loss with the wall, and internal friction is accounted for already by the viscosity. Again, unless the fluid is non-Newtonian (viscosity depends on shear rate), this is already accounted for in Poiseuille flow.

When I say friction I mean internal friction from shear, transmitted to the wall via the no slip condition. This is the main thing that causes the pressure loss in the pipe.

There should not be turbulent flow in normal conditions- especially in an IV line, because turbulent flow introduces cavitation (or at least entrains air bubbles in the flow) which would be disastrous to your body. The expression *does* explain the dynamics, to some degree- the pressure at the nozzle inlet is given by the weight of the fluid. Change the amount of fluid (using multiple bags, etc) and the weight changes.
I suppose you are right about the laminar flow. I tend to work on larger scales where Reynolds no is big.

He probably got scared off long ago :)



My students know I love simple questions that have complicated answers. At a AAPT New Faculty Workshop, I had the quite discomforting experience of taking the 'Physics IQ Test" directly from Prof. Berg (U. Maryland):

http://education.jlab.org/scienceseries/physics_iq.html

I won't say what I got (but if I may brag, I did better than most)- I was so crushed, I spent the next few months in correspondence with Dr. Berg trying to understand how I could possibly teach Physics, since there was ample evidence that I understood nothing. He's a very nice individual- his questions are designed to perplex.

The weight of fluid drives the flow which is mg, which gives the pressure \rho g h The pressure loss described in posseoulli (?) which is due to wall shear scales like QL/a^2

If you add up the pressure losses along each line, they should match the initial pressure head. Let's say all tubes have the same area and roughness and dominate the pressure losses over any valves etc.. The tube from beaker 1 to the junction is length L_1 and carries flow Q_1. The tube from beaker 2 to the junction is length L_2 and carries flow Q_2. The tube from the junction on is length L_3.

Taking the path from beaker 1.

\rho g h = Q_1 L_1/a^2 + (Q_1+Q_2)L_3/a^2

Taking the path from beaker 1.

\rho g h = Q_2 L_2/a^2 + (Q_1+Q_2)L_3/a^2

Combining these two equations for two unknowns gives
Q_1+Q_2 = a^2 \rho g h (L_1+L_2) /(L_1 L_2+ L_2 L_3+L_3 L_1)

If L_3 is much smaller than L_! or L_2 then the flow is just the combination of the two other flows

Q_1+Q_2 = a^2 \rho g h /L_1 + a^2 \rho g h /L_2

If L_3 is much larger than L1 or L2, then the flow rate depends just on the hydrostatic drop in head and the length of the downstream hose.

Q_1+Q_2 = a^2 \rho g h /L_3

I think you could probably set up an analogous experiment with electric current with bits in series and parallel, but that is probably by the by.

I'll do the experiment once I can get a suitable bit of hose.

Charlie
 
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  • #32
You guys are overlooking conservation of momentum at the nozzles. When the velocity of the flow increases due to a decrease in pipe diameter there is a pressure drop that is proportional to the square of the flow rate. That means you would need four times the pressure to double the flow rate if there was a needle or catheter at the end of the pipe. The simplest way to increase the flow would be a larger diameter needle.
 
  • #33
Andy Resnick said:
Here's the setup:

[PLAIN]http://img864.imageshack.us/img864/6328/dsc7101x.jpg 2 500 ml sepratory funnels connected to a common nozzle, as I described. The procedure is simple- fill the funnels and measure the amount of time needed to drain the funnel. Each funnel is at the same height, each funnel was filled to the same level. Each stopcock has a different bore diameter- I have a working lab, and these were the only pieces of glassware available.

Here's the data: individual drainage times

Funnel # 1: 42 +/- 3 s
Funnel # 2: 101 +/- 12 s

And the times when both were allowed to drain simultaneously:

Funnel # 1: 41 +/- 2 s
Funnel # 2: 107 +/- 3 s

The drainage times were unchanged. Thus the flowrate was changed, thus the driving pressure through the nozzle was changed. It doesn't get much simpler than that.

I cannot emphasize enough, this is why *you* need to do actual experiments, not just sit around and think about experiments. I am truly concerned at the attitude expressed by certain individuals in this thread.

I see the problem here. You are misinterpreting the data, since your apparatus is not testing the phenomenon that you believe it is.

The fact that your two funnels drain in dramatically different times indicates that each is being restricted at a separate location. If they were both restricted by the small pipe past the T-joint, they would both drain in approximately the same time. However, the dramatically different drain times indicate a different restriction. I suspect that your stopcocks are the actual flow restricting elements. Since the stopcocks are providing the majority of the flow restriction, they also contain the majority of the pressure drop in the system. As a result, the delta P across the common pipe section shared by both funnels is effectively zero. When both funnels are draining simultaneously, the flow rate through the common pipe section is larger than it was with either funnel draining individually, resulting in a higher pressure loss across the common pipe section than with either funnel individually. However, since the pressure drop was so small to begin with, even the increased pressure drop is relatively minimal compared to the pressure drop across the stopcocks. Because of this, the pressure drop for each side remains basically independent, and dominated by the stopcocks, resulting in the same drain times when both drain simultaneously as when each drains individually. It certainly doesn't demonstrate what you believe it does, since the pressure by the time the fluid gets to the T connection is basically at the ambient pressure, anyways.

In order to properly test this, your apparatus would need the majority of the pressure drop in the system to occur after the two lines have joined. You could achieve this readily with your current setup simply by restricting the flow after the T until the new element in the system became the major restriction (which would be readily apparent, as both funnels would drain in approximately the same time if this were the case, and the time to drain would be substantially longer than either of the individual drain times right now). In that case, the time to drain would be twice as long with both funnels open compared to either one individually.
 
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  • #34
cjl said:
I see the problem here. You are misinterpreting the data, since your apparatus is not testing the phenomenon that you believe it is.

The fact that your two funnels drain in dramatically different times indicates that each is being restricted at a separate location. If they were both restricted by the small pipe past the T-joint, they would both drain in approximately the same time. However, the dramatically different drain times indicate a different restriction. I suspect that your stopcocks are the actual flow restricting elements. Since the stopcocks are providing the majority of the flow restriction, they also contain the majority of the pressure drop in the system. As a result, the delta P across the common pipe section shared by both funnels is effectively zero. When both funnels are draining simultaneously, the flow rate through the common pipe section is larger than it was with either funnel draining individually, resulting in a higher pressure loss across the common pipe section than with either funnel individually. However, since the pressure drop was so small to begin with, even the increased pressure drop is relatively minimal compared to the pressure drop across the stopcocks. Because of this, the pressure drop for each side remains basically independent, and dominated by the stopcocks, resulting in the same drain times when both drain simultaneously as when each drains individually. It certainly doesn't demonstrate what you believe it does, since the pressure by the time the fluid gets to the T connection is basically at the ambient pressure, anyways.

In order to properly test this, your apparatus would need the majority of the pressure drop in the system to occur after the two lines have joined. You could achieve this readily with your current setup simply by restricting the flow after the T until the new element in the system became the major restriction (which would be readily apparent, as both funnels would drain in approximately the same time if this were the case, and the time to drain would be substantially longer than either of the individual drain times right now). In that case, the time to drain would be twice as long with both funnels open compared to either one individually.
I posted early to this thread (think the first) but then backed off and calmly tried to consider the different opinions. I think cjl's last post is the correct explanation as I was looking at the relative restrictions in the test and was thinking the same thing.

Someone earlier, I think marcusl, mentioned the idea of removing partitions in a tank will not increase pressure.

I just don't think you can create a pressure multiplying pump by connecting elevated reservoirs in parallel. Take the static case: A pressure gauge in a small reservoir and many separate branches with a valve connected to separate reservoirs at the same height. If I open the valves, one-by-one, I don't think the gauge will read a higher pressure.
 
  • #35
cjl, it depends what the experiment is trying to show. It certainly shows that the flow through an IV can in some situations be increased if you add more bags, as long as the pressure drop from each bag is mainly upstream of the junction. It also shows that the pressure drop downstream of the junction doubles when you add another bag which doubles the flow rate.

It does not imo contradict \rho g h
but I don't think anyone is claiming that. It shows that in some sense mg/A holds, but as we both suggested, this requires a specific scenario and fairly careful interpretation of what the terms and assumptions apply to.

As for adding the bag reducing the flow as was originally seen by the nurse, I think it would also be interesting to reproduce this in the lab. If the flow from the junction to the second bag had lower pressure drop than from the junction out, then you could find that the bag reduced the flow in the needle. I would have thought that there would have been one way valves to prevent this happening though. It also suggests that adding a second bag to that line like the guy explained may not be the safest way to increase the flow rate.
 
  • #36
cjl said:
I see the problem here.

You most certainly do not. Your comments demonstrate a complete lack of comprehension and understanding. Talking with you further is a waste of time.
 
  • #37
edgepflow said:
If I open the valves, one-by-one, I don't think the gauge will read a higher pressure.

Why don't you do this experiment and report the results?
 
  • #38
Andy Resnick said:
You most certainly do not. Your comments demonstrate a complete lack of comprehension and understanding. Talking with you further is a waste of time.

If that's the case, then would you please explain to me what the problem with my explanation is.

I should note here that I could say the same thing about you. Your comments demonstrate a complete lack of understanding of basic fluid mechanics, including a severe misinterperetation of a simple experiment, and talking with you seems to be a waste of time. I'm mainly continuing to post so that others are not misled by your uncomprehension.
 
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  • #39
sams_rhythm said:
cjl, it depends what the experiment is trying to show. It certainly shows that the flow through an IV can in some situations be increased if you add more bags, as long as the pressure drop from each bag is mainly upstream of the junction. It also shows that the pressure drop downstream of the junction doubles when you add another bag which doubles the flow rate.

Well, I wouldn't say that the pressure drop downstream of the junction doubles, since flow rate and pressure are not always linearly related. However, that is a good point - if the flow restriction were prior to the junction, you could indeed increase the flow rate by adding more bags in parallel. I've always been assuming that the needle was the primary restriction.
 
  • #40
Andy Resnick said:
Why don't you do this experiment and report the results?
Mr. Resnick,

I would like to do this test, but I am not sure my wife would agree to buying piping and pressure gauges :smile:

However, there is a good discussion related to this in "Mechanical Engineering Reference Manual for the PE Exam" 10th Edition, Lindeburg, Section 15-4 & Figure 15.6. The figure shows four unconnected open columns on top of a common reservoir. It states:

"Pressure is independent of the object's area and size and the weight (mass) of water above the object. Figure 15.6 illustrates the hydrostatic paradox. The pressure at the depth h are the same in all four columns because pressure depends on depth not volume."

Please also consider Figure 1 in this link:

http://scubageek.com/articles/wwwparad.html

And this discussion:

http://wishtrain.com/2009/11/194/

Let me know if you feel this applies.
 
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  • #41
edgepflow said:
Mr. Resnick,

<snip>
Let me know if you feel this applies.

It very much applies- from your first URL:

"The pressure at a point in a static liquid is due entirely to the weight of liquid (plus the atmosphere) directly above it"

Which is what I have been saying all along. You are neglecting the role of the stopcock/valve in my experiment. When closed, it's a rigid dividing surface- think about what the effect is as fluid drains from the other reservoir, and how that relates to "the weight of liquid directly above it".
 
  • #42
cjl said:
[..] your apparatus is not testing the phenomenon that you believe it is.

The fact that your two funnels drain in dramatically different times indicates that each is being restricted at a separate location. If they were both restricted by the small pipe past the T-joint, they would both drain in approximately the same time. However, the dramatically different drain times indicate a different restriction. I suspect that your stopcocks are the actual flow restricting elements. Since the stopcocks are providing the majority of the flow restriction, they also contain the majority of the pressure drop in the system. As a result, the delta P across the common pipe section shared by both funnels is effectively zero. [..]
In order to properly test this, your apparatus would need the majority of the pressure drop in the system to occur after the two lines have joined. [..] In that case, the time to drain would be twice as long with both funnels open compared to either one individually.

Good analysis. :smile:

This discussion deviated from the rather surprising (at least for me) observation of the OP. The vortices/turbulence explanation sounds good to me, but I did not expect the effect of a standard T connector to be so pronounced.

Still, this effect was already discovered by Tesla who patented an extreme embodiment of the same, by means of which we can almost block the main flow from by injected flow from the side, slightly in counter sense:

http://www.google.com/patents?id=Lt1PAAAAEBAJ&printsec=drawing&zoom=4#v=onepage&q&f=false

Note that this effect already works in the laminar flow regime as soon as inertial effects become significant.

Cheers,
Harald
 
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  • #43
Andy Resnick said:
It very much applies- from your first URL:

"The pressure at a point in a static liquid is due entirely to the weight of liquid (plus the atmosphere) directly above it"

Which is what I have been saying all along. You are neglecting the role of the stopcock/valve in my experiment. When closed, it's a rigid dividing surface- think about what the effect is as fluid drains from the other reservoir, and how that relates to "the weight of liquid directly above it".

It's relatively straightforward. At the opening of each funnel, the pressure (purely from a hydrostatic analysis of the water in the funnel) is equal to ρgh. Note that this is not identical to the weight of the water divided by the cross sectional area of the throat (which would be much greater than ρgh). This is because at every point where the liquid is contacting the walls of the funnel, the walls of the funnel are pushing back on the liquid (an equal and opposite reaction, you could say). However, since this is a hydrostatic analysis, there is no shear between the liquid and wall. As a result, the force must be perpendicular to the wall. In any section of a container in which the diameter is decreasing as you go downwards, the normal to the wall must have an upwards component.

Since the force between the liquid and the wall must be normal to the wall (assuming a hydrostatic problem, again), the force the wall exerts on the liquid has an upwards component. To determine the pressure at the exit, you have to integrate the force all the way around the control volume, then sum the forces and set them equal to zero.

Now, for some surface inclined to the vertical at some angle, the component of the overall pressure force acting upwards is equal to the overall pressure force multiplied by the sin of that angle (since we are defining the angle as relative to the vertical).

To initially simplify the analysis further, I'll first look at the case for which there is a constrained column of water in a container with vertical walls, and a bottom surface inclined to the vertical with some angle (basically, a beveled cylinder or prism). I'll also assume the depth of the water is sufficient such that the difference in depth from one side of the bottom surface to the other is insignificant (basically, consider an infinitesimal sloped element as the base). The weight of the liquid is mg, which is equal to ρghA, in which A is the cross sectional area. Since the bottom section of the tube is inclined however, the area of the inclined region is equal to A/sin(theta), in which theta is the inclination angle to the vertical. The force on this region is equal to P*A/sin(theta). Based on what I've already described above, the vertical component of this is equal to sin(theta)* P*A/sin(theta), which simplifies to P*A. Thus, the vertical component of the pressure force on the inclined surface perfectly balances the weight of the column of water above it by simple fluid statics.

When we consider that the vertical walls in this container could be replaced by a fluid surface and nothing would change about the situation, it can be seen that this situation can be generalized to any situation in which there is a container with fluid and inclined walls. One such case is a funnel.

In a funnel, much of the fluid is directly above an inclined surface. For the same reason as above, any fluid above such a surface has its weight supported by the pressure force on the region of inclined surface directly below it. Thus, the only fluid for which the weight is not fully supported is the fluid directly over the funnel outlet. This column of fluid must necessarily have the same cross sectional area as the funnel outlet. Thus, the pressure at the funnel outlet is equal to the weight of this fluid (ρghA) divided by the area of the outlet (A), giving P = ρgh.

Now, if I take two funnels, each filled to the same level with the same fluid, and attach the outlets of each together with a valve separating them, this clearly shows that the pressure on each side of that valve will be identical, and equal to the density of the fluid multiplied by the gravitational acceleration of the environment in which they reside, multiplied by the height of the free surface of the fluid above the height of the valve. Once again, any time when there is a surface in a static liquid, it can be replaced with a liquid surface at the same pressure and nothing will change about the problem. Therefore, if the valve is removed, it is effectively replacing a solid surface with a liquid surface at the same pressure in this situation, and nothing changes. With two funnels, the pressure is unchanged compared to a single funnel.

Note that all of the analysis to this point assumes a purely static liquid. Thus, there are no inertial effects, nor are there any viscous effects. That is clearly not the case in several of the experiments before. However, for small flow rates and relatively unrestricted piping, it is a reasonable approximation. For example, in your funnels which drain in timescales of minutes, there will not be substantial inertial or viscous effects within the funnel itself.

Now that I've shown from rather basic principles that adding a second funnel does not in fact double the static pressure at the outlet, why does your experiment have a substantially changed flowrate between the various cases?

The answer is in the assumptions. In any real system, especially with flow through a relatively small orifice, there will be substantial viscous losses. These cause a pressure loss through each component, and the magnitude of the loss depends on the specifics of the flow through each element.

In many cases, the loss will primarily happen at one (or a small number of) restricting element. If this is the case, the pressure loss across the restricting element will be very large, while the pressure loss across the other parts of the flow will be minimal. This is what is happening with your setup and with the IV. However, the restrictive component in your setup is prior to the junction (likely the stopcock). As a result, the pressure at the junction is far below the pressure at the bottom of the funnel, and likely very close to ambient (rather than the substantially above ambient pressure that exists at the bottom of the funnel). This means that when both funnels are open, the primary flow restriction (the stopcocks) does not have any more flow through it than it did when the funnels were open separately, since the flow through either individual stopcock is never fed by both funnels.

To illustrate why this is not showing what you believe it is, I'll use a simple numerical example. I'll also assume pressure drop across an element is linearly proportional to flowrate. It isn't, but it will work for the purpose of this example. I'll also assume two identical funnels, rather than the dissimilar ones like you are using.

Suppose that the pressure drop across the stopcock at the bottom of each funnel is 90% of the total pressure loss of the system, and the pressure loss below the junction is 10%. Individually, the funnels drain in 100 seconds. When both funnels are draining simultaneously, the total pressure drop must remain constant, since the outlet pressure and the feed pressure have not changed. However, the flowrate through the area below the junction is now double the flowrate through the stopcocks. Thus, relative to the pressure drop through the stopcocks, the pressure drop through the junction must have doubled. Since it was originally 1/9 the pressure drop through the stopcocks, the new pressure drop through the junction must be 2/9 the pressure drop through either of the stopcocks. Since the total must add up to 100%, this means that with both funnels feeding it, the new distribution of pressure is 18.2 percent through the junction, and 82.8 percent through the stopcocks. This means the flow rate through each stopcock is (82.8/90) of what it was before.

This means that although the feed pressure was unchanged, the flowrate through the junction is up to 1.82 times the flowrate with either funnel individually opened. Similarly, each funnel will now drain in 108.7 seconds, which is only slightly longer than it took individually.

If you bias the numbers even more (less pressure drop through the junction, more through the stopcock), you can make the drain time with both funnels feeding arbitrarily close to the single funnel drain time, even though the pressure drop never changes. However, if you increase the flow restriction after the junction, the drain time substantially rises, and if the majority of the pressure drop occurs after the junction, then the flow rate will be largely unaffected by the number of funnels feeding (and thus, the drain time for two funnels will be basically twice the drain time for one). This clearly shows the flaw in your argument - you assume that the increased total flow rate indicates an increased feed pressure, when in reality, it only indicates where the flow restriction in your setup resides.


(Sorry for the rather extensive essay, but I am trying to explain this as clearly as I can).

I'll try to scrounge up materials to demonstrate this experimentally later tonight. I don't have access to nice glassware like you do, but I should be able to find enough material to make this work.
 
  • #44
Hello, I am new to these forums.

Friction limits velocity. The apparatus has a depreciating return in terminal velocity at a certain pressure input value as a result of the friction (think of a sonic boom). If the fluids are moving too fast, there will be excess turbulence and heat. The input vector of the IV will also become significant when the resulting velocity is high. Based on the original experimental result, I would expect that the IV to be small and the fluid output to be fast. The friction problem could be tested by putting the IV is a denser medium (water) during the test. The flow rate should increase when the vibrations are dampened.

In summary, the increase in pressure is being radiated in energy forms that dampen and resist flow. I could be mistaken.
 
  • #45
mixinman7 said:
Hello, I am new to these forums.

Friction limits velocity. The apparatus has a depreciating return in terminal velocity at a certain pressure input value as a result of the friction (think of a sonic boom). If the fluids are moving too fast, there will be excess turbulence and heat. The input vector of the IV will also become significant when the resulting velocity is high. Based on the original experimental result, I would expect that the IV to be small and the fluid output to be fast. The friction problem could be tested by putting the IV is a denser medium (water) during the test. The flow rate should increase when the vibrations are dampened.

My experiment was carried out with a Reynolds number of about 4. How can you possibly justify invoking "excess turbulence and heat"?

mixinman7 said:
I could be mistaken.

Quite.
 
  • #46
I have to say I agree with cjl here. The key here in the experiment is the use of a stopcock. Stopcocks are designed specifically to restrict flow, even at their fully open position. They are not just simple valves. The difference is that a stopcock is made to have a smaller diameter than the tubing it connects to, so the maximum flow rate that can be sustained by a stopcock is less than that of the larger diameter tube if it was connected without a stopcock.

Your total mass flow coming through those stopcocks will always be less than the total mass flow through just the tubes for a given pressure or fluid arrangement. It is as cjl has said, the stopcocks are governing your flow, not your tubing. The experiment is not actually testing what it was supposed to have tested.

Look at it in terms of a control volume. If you have one bag (or bucket or funnel or whatever reservoir you like) connected to one line, the control volume is the whole system, from the top of the bag to the orifice through which it exits the IV. While it is true that the Bernoulli equation can't handle viscosity, it can be applied to a control volume to get the average velocity - and therefore mass flow rate - through the control volume. In that frame of mind, the pressure at the exit is \rho g h and the average velocity is dependent on that pressure. The mass flow is dependent on that area, A, and the velocity.

Now hook up two bags that T together and come out of the same sized final orifice with all bags and the exit at the same respective heights. The pressure is still \rho g h and the area is still A, so that mass flow rate is still the same.

Were it not for the stopcocks restricting the flow, the exit mass flow rate would be the same in each test for the aforementioned experiment assuming there were no mixing effects at the T-junction. In the case of the OP's question, the mixing effects are certainly a factor and would introduce additional pressure losses, decreasing the total mass flow.
 
  • #47
Hello Andy Resnick.

You have my apologies. I was not referring to your lab test. I was referring only to the test in the original post. IVs are very flexible small diameter tubes with considerable length. I guarantee that turbulence will be a significant factor in a test set up with small diameter tubes with appropriate lengths. With your test, the tubes were of short length, and therefore stiff with a much higher resonant frequency. An interference oscillation will be simple to create in a long flexible, narrow tube, and difficult to create in a short stiff tube of greater diameter. The lab test using only readily available materials is not adequate to test for the interference I suspect produced the flow results in the original post.

After boneh3ad response, I realized that the larger turbulent influence would be at the terminal end, not within the tubing. I would ask whether the original poster had a needle on the end of the IV, and whether it was hanging freely over the edge of the receiving container. Did the needle wobble back and forth while hanging over the bucket edge, and was it a notably more severe wobble with two IVs serving the one needle?

Last, in reference to the original premise, I would suggest that two IVs hooked up to an actual patient might drain faster than two separately. The experiment in the original post might have neglected critical factors such as what the terminal end of the IV was leading to, or the relative heights of the bags or the terminal end. Alternatively, the drain might have been much slower since the capacity resistance of the veins would be factors. I can't predict what will happen. I am only an undergraduate in radiologic science, and am discussing concepts, not math equations (Radiologic technology student).

"How can you possibly justify invoking "excess turbulence and heat"?" by Andy Resnick

Heat would be a negligible factor, but turbulence is notable when considering the length, flexibility, diameter, and terminal end of the IV. I have been reading through much on the forums, and found this topic very interesting. I am intending only to add a concept to the discussion that seems to be absent.

Cheers
 
  • #48
Turbulence is nearly a non-factor. The Reynolds number is going to be incredibly small given the tiny diameter involved and the relatively low speeds.

Let's say, for grins, the tube ID is 0.5 mm. That would come out to roughly 4 m/s before the flow goes turbulent. That isn't likely to happen considering IV bags are usually only a couple feet higher than the entry point. Additionally, assuming the IV had a drip, the actual pressure is dictated by the fluid height in that drip, not the bag, and that is considerably smaller.
 
  • #49
Sigh. Maybe this thread is hopelessly frayed, but I will try one more time to present a correct analysis.

The OP asked a simple question- how can s/he maximize the delivery of fluid through an IV line to a patient? My answer is "use of two (identical) IV bags will deliver fluid at twice the rate of a single bag", and this answer seems to have caused a lot of confusion.

The first conceptual error occurred when posters tried to treat this as a hydrostatic problem. Certainly, a limit can be taken whereby this problem does become static (specifically, use of a IV bag of infinite volume), but this is not useful. This is a problem of *flow*, not static pressures.

The next conceptual error occurred when posters attempted to quantify the role of where the flow is "restricted"- the needle, the valve, the tubing, etc. Disposing of this error requires a more precise statement of the problem, but for now, let's assume the needle has the smallest diameter of any of the other parts of the system. Thus, we can focus only on the role of the needle on regulating the flow of fluid from the IV bag to the patient.

What controls the flow through the needle? Lots of parameters: the fluid density, the fluid viscosity, the radius of the needle, and the difference in pressure between the ends of the needle. This is the principal result of Poiseuille flow:

http://en.wikipedia.org/wiki/Hagen–Poiseuille_equation

Note- I am using the flow rate Q as the dependent variable, not the pressure difference.

As a practical matter, the flow rate can most efficiently be increased by increasing the needle diameter- doubling the diameter results in a 16-fold increase in flow rate, keeping everything else constant.

But let's say that not only are the physical properties of the fluid fixed (the density and viscosity), but the needle diameter is also fixed- we must use a hypodermic needle of a certain size. What can we control? The pressure difference between the needle inlet and needle outlet.

We can't control the pressure at the outlet- it's inside the patient- but we can assume it is a constant. We can also, for the sake of this analysis, set the constant outlet pressure to atmospheric pressure: the IV now drains into open air rather than a vein or subcutaneous tissue. So all we can control is the pressure at the entrance to the needle. What is this pressure?

Let's consider a simple system- two vertical tubes, open to the atmosphere at the top, joined to a single horizontal tube at the base, in the center of which is a t-junction, and the outlet of the t-junction leads to the needle. All tubes and connectors are of identical diameter (except for the needle), and let's also add a thin guillotine-like valve in one of the tubes. This valve is made of unobtanium: infinitely thin, infinitely stiff, and when it is withdrawn no fluid leaks out of the side of the tube. Again, because the needle is the smallest diameter tube, we only need specify the pressure at the needle inlet to fully determine the flow rate.

With the valve open and needle outlet plugged, we fill the two tubes. We should all be able to specify the pressure everywhere. Closing the valve at this point changes nothing- that's clear. But I'll close the valve all the same. Hopefully, you will have noticed I did not specify *where* the valve is. I did not specify the location because it doesn't matter (within reason- putting the valve at the very top would be silly)

Now I unplug the needle and allow fluid to drain freely. What happens? The flow rate through the needle is proportional to the amount of fluid remaining in the open tube- specifically, the *weight* of the fluid remaining in the open tube. This should be obvious as well, since the IV won't drain at all if we were on the International Space Station and tried to do this- there, we would have to apply a pressure to the IV bag to force fluid through the needle.

Now let's consider what happens if instead of closing the valve, I leave it open. Initially, there is no difference. But, as fluid starts draining, there *is* a difference- the valve is no longer holding up a mass of fluid, which is now free to press upon the needle. Thus, the weight of fluid pressing on the needle inlet is *greater* than before. In case this seems counter-intuitive, think about what would happen if you open the valve *during* the time fluid is draining.

This is what my experiment showed- that adding a second IV bag increases the weight of fluid pressing in the needle inlet, increasing the pressure, and increasing the flow rate. The roles of turbulence, friction (other than viscosity), location of 'flow restriction' etc. do not matter- the only thing that controls the flow through the needle is the value of the pressure at the needle inlet, and this is indeed given by \rho gh- the difficulty is apparently in understanding that \rho gh is proportional to the weight of the fluid that presses on the needle.
 
  • #50
Andy,

I've given you the correct explanation, both for the OPs situation and for the results of your experiment about a dozen times now in probably 4 or 5 different ways. The fact that your explanation makes intuitive sense to you doesn't change its factual errors.
 
  • #51
Oh, and just to demonstrate it, I just performed the experiment with the flow restriction primarily (but not completely) at the common exit of the two funnels. I couldn't find two identically sized funnels, so the drain times individually were quite different, but I think the results speak for themselves:

Funnel 1 drain time:
1:38.23
1:35.97
1:39.60
1:39.75

Funnel 2 drain time:
27.54
27.74
28.11
27.54

Both funnels together:
1:57.55
1:58.65
2:02.85
1:55.63

As you can see, the flow rate stays roughly constant, while the drain time for both funnels together is only slightly less than the sum of the drain times for each funnel individually. It is also substantially longer than the individual drain time of either funnel (as I predicted several pages ago).
 
  • #52
edgepflow said:
I have a feeling that most of the flow restriction is in the final needle that dispenses the IV into the patient. So you could imagine putting even 10 hoses connecting together into the one needle.

Agreed. No matter how many bags you hook up, it will ultimately come down to how much liquid you can get through the tubes and the needle. Larger tube and needle = more flow. But in the case of IV tubes, i'd say there are designed to be the correct size for one bag and produce the correct flow rate into a patient.

Adding an extra bag, it would be more than likely that one bag would flow at a greater rate than the other as the line is designed for a single bag?

You could pimp out the IV bag with some small garden hose and a larger needle, but i wouldn't like to be that patient! :P
 
  • #53
Andy_Resnick said:
The OP asked a simple question- how can s/he maximize the delivery of fluid through an IV line to a patient? My answer is "use of two (identical) IV bags will deliver fluid at twice the rate of a single bag", and this answer seems to have caused a lot of confusion.

Because it is wrong. Adding two bags does not double the flow rate.

Andy_Resnick said:
What controls the flow through the needle? Lots of parameters: the fluid density, the fluid viscosity, the radius of the needle, and the difference in pressure between the ends of the needle. This is the principal result of Poiseuille flow:

Poiseuille flow, while the correct flow for this situation, is not needed to solve this problem. You don't need to know the velocity profile at a given point in the tubing or needle to know the flow rate, adn that is what Poiseuille flow gives you.

Andy_Resnick said:
As a practical matter, the flow rate can most efficiently be increased by increasing the needle diameter- doubling the diameter results in a 16-fold increase in flow rate, keeping everything else constant.

If you hold velocity constant (and density is obviously constant), doubling D quadruples the mass flow rate. After all, the formula for area only depends on D^2, so doubling D gives you a factor of 4, not 16.

Andy_Resnick said:
So all we can control is the pressure at the entrance to the needle. What is this pressure?

This is, in fact, one of the pressures that can be used to answer this problem. It is dependent on the velocity of the fluid at that point plus the static pressure. Of course, that can be easily deduced by simplifying the whole problem and looking at it as a control volume containing everything from the bag (or bags) to the needle. Since it is a control volume, you can still use the Bernoulli equation to get the average exit velocity, despite the fact that there are viscous effects inside). When I say average velocity, I mean the velocity that produces the same mass flow rate out of a given area as integrating the true velocity profile. I promise you, Bernoulli's equation absolutely applies to get that and is used all the time.

So, what does this simplified system mean? It means you can ignore the velocity going through the system. And only worry about the pressure from the reservoir and the exit pressure. As you stated, the exit pressure is fixed. The pressure of the reservoir, however, is entirely determined by two things: height of the reservoir and atmospheric and other external pressures. It has nothing to do with the amount of fluid in the bag or the number of bags hooked up. It only depends on the highest point the fluid reaches above the exit. In other words, the only way to increase the pressure without changing the diameter of the tubes or the needle is to either lift the bag higher or squeeze it (either with your hands or an external pressure of some kind, it doesn't matter).

Again, your original experiment was flawed based on the fact that the stopcocks were governing the flow rate, not the tube size. The combined mass flow allowed by the stopcocks was simply lower than the maximum allowed by the tubes, thereby allowing the bags to drain at the same rate together as a single bag. You would need a valve capable of passing at least the same mass flow as the tube in order to truly test the variable you think you are. These valves do exist aplenty, but stopcocks are not an example of them.

Andy_Resnick said:
This should be obvious as well, since the IV won't drain at all if we were on the International Space Station and tried to do this- there, we would have to apply a pressure to the IV bag to force fluid through the needle.

You have identified the proper force that is driving the flow. You just have a fundamental misunderstanding about how it is applied. It all comes down to a force balance. You can show that the force on a differential element is:
dp = -\rho g \; dy
If you integrate this from the fluid element of interest (the exit plane in our case) to the very top surface of the fluid in the reservoir (meaning the heighest point of fluid in the control volume), you get:
\Delta p = -\rho g \Delta h
Note that while this is still fundamentally a gravity force on the fluid, it has nothing to do with mass directly, but only with density, which is invariant with respect to the size of the reservoir or the number of reservoirs. In other words, we know \rho and g and we can't change either of these. Clearly, the only variable is then \Delta h and the pressure (which in your case is simply the pressure drop since there is atmospheric pressure on both ends) is simply the resulting hydrostatic pressure.

What does this mean? It means the size of the reservoir and amount of fluid plays no role in the resulting pressure and flow rate other than how full the container is, since the fluid in a fuller container will reach higher.

Of course, this is a hydrostatics example. For this problem, we need a moving fluid. Enter Bernoulli's equation, which has the same form as the hydrostatic equation, only including motion terms. If we look at the same two points at the top of the reservoir where the velocity is zero and at the exit of the needle, you can write Bernoulli as:
p_{\textrm{exit}} + \rho g y_{\textrm{exit}} + \frac{1}{2} \rho v_{\textrm{exit}}^2 = p_{\textrm{res}} + \rho g y_{\textrm{res}}
However, here, p_{\textrm{exit}} and p_{\textrm{res}} are both atmospheric pressure (in the case of a real IV, you would have a term representing the difference between blood pressure and atmospheric pressure). These terms cancel out, leaving:
\rho g y_{\textrm{exit}} + \frac{1}{2} \rho v_{\textrm{exit}}^2 = \rho g y_{\textrm{res}}
We then move the y terms to the same side. Note that these two terms are arbitrary, and as long as they are taken with respect to the same origin, they can be anything since only their difference matters. For simplicity, we will assume that y_{\textrm{exit}} is the origin and therefore zero and y_{\textrm{res}} just represents the height of the reservoir bag above the exit plane. This leaves us with:
\frac{1}{2} \rho v_{\textrm{exit}}^2 = \rho g y_{\textrm{res}}
This can obviously be solved for the exit velocity:
v_{\textrm{exit}} = \sqrt{2 g y_{\textrm{res}}}
The mass flow rate is then trivially:
\dot{m} = \rho v_{\textrm{exit}} A_{\textrm{exit}}
\dot{m} = \frac{1}{4} \rho \pi D_{\textrm{exit}}^2 \sqrt{2 g y_{\textrm{res}}}

Note that the only parameters that we have control over in this scenario are D_{\textrm{exit}} and y_{\textrm{res}}. It does not depend on the number of reservoirs, the total amount of fluid in the reservoirs or anything other than these parameters.

Also note that while your assumptions made the pressure terms drop out, leaving them in by either actually assuming blood pressure or applying a pressure to the reservoir surface(s) would be easy and would just result in a \Delta p term that is also not dependent on the number of reservoirs or the total amount of fluid in the reservoirs.
 
  • #54
cjl said:
Oh, and just to demonstrate it, I just performed the experiment with the flow restriction primarily (but not completely) at the common exit of the two funnels. I couldn't find two identically sized funnels, so the drain times individually were quite different, but I think the results speak for themselves:

Funnel 1 drain time:
1:38.23
1:35.97
1:39.60
1:39.75

Funnel 2 drain time:
27.54
27.74
28.11
27.54

Both funnels together:
1:57.55
1:58.65
2:02.85
1:55.63

As you can see, the flow rate stays roughly constant, while the drain time for both funnels together is only slightly less than the sum of the drain times for each funnel individually. It is also substantially longer than the individual drain time of either funnel (as I predicted several pages ago).
I think the reason the drain time of both funnels together is a little less than the sum of the individual times is the extra "inventory" maintaining a slightly higher average elevation "gravity head" during the test. Of course, the addition of the second funnel does not at any time increase the maximum gravity head.
 
  • #55
boneh3ad said:
\dot{m} = \rho v_{\textrm{exit}} A_{\textrm{exit}}
\dot{m} = \frac{1}{4} \rho \pi D_{\textrm{exit}}^2 \sqrt{2 g y_{\textrm{res}}}

Note that the only parameters that we have control over in this scenario are D_{\textrm{exit}} and y_{\textrm{res}}. It does not depend on the number of reservoirs, the total amount of fluid in the reservoirs or anything other than these parameters.
Good treatment, that is what I would expect. I mentioned several posts ago that adding reservoirs in parallel would not have a pressure multiplying effect, although you will see a small increase in the average flow as cjl measured.

If there was a pressure multiplying effect with parallel reservoirs, we could create some pretty cool pressure and flow control loops. Imagine a ring array of reservoirs and actuated valves: if you need more or less flow, just open or close valves. If this were true, there would probably be products like this on the market.
 
Last edited:
  • #56
edgepflow said:
I think the reason the drain time of both funnels together is a little less than the sum of the individual times is the extra "inventory" maintaining a slightly higher average elevation "gravity head" during the test. Of course, the addition of the second funnel does not at any time increase the maximum gravity head.

I agree with this as the most likely explanation - the way the experiment was set up, the last portion of the drainage was largely independent of reservoir volume, so it always took about the same time. Since the reservoir drainage took longer in the case where both funnels were open, the average head was slightly higher for the two-funnel case than for the one-funnel case. It's a relatively small effect, but enough to be visible in the results as a slight disparity between the drain time of both funnels together and the sum of the individual drain times.
 
  • #57
edgepflow said:
If there was a pressure multiplying effect with parallel reservoirs, we could create some pretty cool pressure and flow control loops. Imagine a ring array of reservoirs and actuated valves: if you need more or less flow, just open or close valves. If this were true, there would probably be products like this on the market.

Interestingly enough, it would also allow for free energy and perpetual motion.
 
  • #58
boneh3ad said:
Because it is wrong. Adding two bags does not double the flow rate.
Indeed, and that was already described in the OP.
Poiseuille flow, while the correct flow for this situation, is not needed to solve this problem. You don't need to know the velocity profile at a given point in the tubing or needle to know the flow rate, adn that is what Poiseuille flow gives you.
Right, you only need to take in account that some of the energy goes into friction.
[...] Since it is a control volume, you can still use the Bernoulli equation to get the average exit velocity, despite the fact that there are viscous effects inside). When I say average velocity, I mean the velocity that produces the same mass flow rate out of a given area as integrating the true velocity profile. I promise you, Bernoulli's equation absolutely applies to get that and is used all the time.
That is also wrong except if the Poisseuille friction term is very small compared to the Bernoulli terms.

Regards,
Harald
 
  • #59
harrylin,

Except in the case of very fast flow or very small tubes, the friction losses would be very small. Regardless, if we approach this from the eyes of a mechanical engineer, we could easily introduce a head loss term to fairly accurately account for the effect of viscous losses. You could theoretically do the same for the loss associated with the T-joint.

The important thing is that neither of those additional loss terms will depend on the number of reservoirs or amount of fluid in each reservoir.
 
  • #60
boneh3ad said:
Except in the case of very fast flow or very small tubes, the friction losses would be very small. if we approach this from the eyes of a mechanical engineer, we could easily introduce a head loss term to fairly accurately account for the effect of viscous losses. You could theoretically do the same for the loss associated with the T-joint.
The friction term can be neglected in the case of fast flow through a large opening: Poisseuille flow scales with v while the kinetic energy term scales with v2.
The important thing is that neither of those additional loss terms will depend on the number of reservoirs or amount of fluid in each reservoir.

Yes of course (that is well understood), except for the issue of the OP which, as I and others suggested, relates to the T connector; and I gave a reference to a practical application of that phenomenon by Tesla. :smile:
 
Last edited:

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