Genetic Engineering Intelligence

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Researchers at Princeton genetically engineered mice to enhance intelligence, raising questions about similar applications in humans. Current discussions focus on identifying alleles linked to high intelligence rather than risky genetic modifications. Concerns arise about potential negative consequences of selecting for specific traits, reminiscent of issues faced in dog breeding. Educational interventions, like the Head Start program, have shown promise in developing intelligence-related alleles without genetic manipulation. The complexity of gene interactions suggests that while genetic engineering may one day be possible, nurturing and education remain crucial for cognitive development.
  • #31
dsadsa said:
For our purposes, let's define define intelligence to be proficiency in academic research or the ability to score high on an IQ test.

Government enforced sterilization of people with exceptionally low IQs or an exceptionally poor proficiency in academic research. Couple that policy with forcing people that have exceptionally high IQs or great proficiency in academic research to have high numbers of offspring. This method could be used to enhance/restrict any genetically influenced trait within a population, and probably within a relatively short amount of time. Basically treat people like cattle. Contemporary views on morality and ethics would prevent this from being a popular policy. This would not necessarily produce a better human. It would produce a human that is better at standardized tests or academic research. And that likes Star Trek - a lot.
 
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  • #32
mplayer said:
Government enforced sterilization of people with exceptionally low IQs or an exceptionally poor proficiency in academic research. Couple that policy with forcing people that have exceptionally high IQs or great proficiency in academic research to have high numbers of offspring. This method could be used to enhance/restrict any genetically influenced trait within a population, and probably within a relatively short amount of time. Basically treat people like cattle. Contemporary views on morality and ethics would prevent this from being a popular policy. This would not necessarily produce a better human. It would produce a human that is better at standardized tests or academic research. And that likes Star Trek - a lot.

I've suggested nothing of the sort. I'm not interested in taking any freedom's away from people. Selective breeding isn't that effective anyway.

The definition was not meant to be a perfect one, it was only meant to demonstrate that we could come up with one. If you think some trait (like scoring high on an IQ test) is associated with being intelligent, then you can easily check to see what genes are correlated with that trait.
 
  • #33
dsadsa said:
For our purposes, let's define define intelligence to be proficiency in academic research or the ability to score high on an IQ test. I'm suggesting that we not concern ourselves with the function of genes that are correlated with high intelligence and simply produce a human possessing all of them. We already know everything required for this procedure and since you say we have technology, there's nothing 'holding us back'.

Can you please refer me to a reliable source as to how this works? (the technology used to change the genetics of a blastocyst, I'm not interested in this procedure for an adult given its difficulty)

The thing is, we don't know what genes are actually contributing to the cognitive processes that manifest themselves as observable intelligence. There are just tons and tons of genes that impart function in the brain. What scientists have been trying to do is look for genes common to people with high intelligence. This hasn't yet yielded much success, most likely because high intelligence is a combination between certain neurotransmitter levels, physical brain structure (spatial relationships of neurons, physical formation of neural bodies), and experience as well. These relationships are so complex that it is unlikely a few genes given to any person will make them highly intelligent.

So far there is a small number of genes identified that correlate to high intelligence. If you implant these genes into another person, would they become more intelligent? Or would they just get tumors because their other brain genes are not compatible? I don't know. The reason I believe understanding the actual neurofunctionality of intelligence is so important is because it will tell us exactly what genes to modify.

This is how genetic therapy works:

http://www.ornl.gov/sci/techresources/Human_Genome/medicine/genetherapy.shtml
 
  • #34
As for NR2B, it is unknown if it performs a similar function in humans. Humans have evolved quite distantly from mice, and we have been given a lot of time time find different uses for the same gene.

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-4G4PBYR-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=be58337239176428bea5d5943a801213
 
  • #35
It appears you're right - it seems that the majority of genes that affect intelligence work in combination making the choice of which genes to select less than trivial. Still, the problem is reduced to collecting data and statistical analysis.
 

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