To calculate the temperature distribution in a cube when heat is applied to one side, several variables must be considered, including the material properties, initial temperature, and method of heat application. The heat transfer is not linear due to heat loss from the cube's sides, complicating the calculation. Fourier's law can be applied if the cube is insulated, but in this case, the heat loss must be accounted for as it spreads. A mathematical model can be developed using the heat conduction differential equation, but it may require numerical methods for a solution. Tools like MATLAB or Mathematica can be useful for approximating the results, particularly if an analytical solution is not feasible.