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Help for calculation of the heat of the following reaction

  1. Jun 19, 2015 #1
    Anybody can help for calculation of the heat of the following reaction?

    Some background:
    Ligand X bind to protein M, the product is MX. Binding affinity of X to M is K = [MX]/([M]*[X]).
    [MX], [M], [X] are the concentrations of each stuff after the reaction finished.
    The ratio of MX to total M is θ = [MX]/([M]+[MX]).
    ΔH is the molar heat of M, V is the volume of reaction.
    Mt and Xt is the concentration of total M and X at the beginning of the reaction.
    So, for this reaction the heat Q = θ*Mt*ΔH*V

    My Question is:
    The beginning products: Xt= 50 uM, Mt=400 uM, also some [MX] = 4 um, ( Mt is the total concentration of M, including the M in MX),
    V=200 ul, K= 100000 M-1, and ΔH =-4000
    How to calculate the heat Q for above reaction?

    Tons of thanks!!
     
  2. jcsd
  3. Jun 19, 2015 #2

    Borek

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    Staff: Mentor

    No idea what you mean by that.

    And no idea what the problem is - you are given equation, you are given data, why don't you plug the numbers in?
     
  4. Jun 19, 2015 #3
    Thanks for your post.

    The equation I have is only for M and X at the beginning of the reaction. My question now is there is small amount of MX mixed in the beginning.
     
  5. Jun 19, 2015 #4
    I guess it is hard to calculate θ, just leave it in the final answer
     
  6. Jun 20, 2015 #5

    Borek

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    Staff: Mentor

    Isn't it just a trivial equilibrium problem? Easily solved with an ICE chart? You are given K, you know the reaction equation, you know starting concentrations.
     
  7. Jun 21, 2015 #6
    Thanks! I will try the ICE chart.
     
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