Help in understanding effect size in fMRI

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SUMMARY

This discussion centers on understanding the implications of negative effect sizes in fMRI studies, specifically in the context of the article "Differential extrageniculostriate and amygdala responses to presentation of emotional faces in a cortically blind field." The participant seeks clarity on the significance of a negative effect size related to the amygdala's activation levels, particularly concerning the "unseen CS-." It is established that fMRI measures blood flow to indicate brain activity, but interpretation can be subjective and requires familiarity with specific response characteristics.

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  • Understanding of fMRI principles and blood flow measurement
  • Familiarity with effect size concepts in statistical analysis
  • Knowledge of neural activation patterns, particularly in the amygdala
  • Experience with interpreting neuroscience research articles
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Students in neuroscience, researchers analyzing fMRI data, and professionals interpreting emotional response studies will benefit from this discussion.

dentons
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Hello everyone, I'm a student of a Master's degree in Neuroscience and I'm preparing a journal club presentation on an article called "Differential extrageniculostriate and amygdala responses to presentation of emotional faces in a cortically blind field". I'm struggling to understand some of the results, in particular what a negative effect size means in fMRI. Is there someone that can explain that to me? I'm referring in particular to this picture of the paper https://d1gqps90bl2jsp.cloudfront.net/content/brain/124/6/1241/F4.large.jpg?width=800&height=600&carousel=1 the one attached).
What can I say about the "unseen CS-"? Why is it so negative? Does it mean that the amygdala has a very low degree of activation?
Thanks to anyone that can help me :)
 

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This appears to be something @DiracPool could help with. I'm confused with your explanation as well. fMRI mesures blood flow in the brain which indirectly shows which brain tissues are active. Interpretation is, IMO, sometimes a bit subjective. Each area seems to require the reader to be in the know how the ground rules are applied. My opinion only. In particular you have to have a solid grip on the particular known aspects of certain kinds of responses.
 

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